A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management
Background. Hemodynamic-guided therapy using the CardioMEMS™ system has been shown to reduce heart failure hospitalization (HFH) in both clinical trials and real-world settings. However, the CardioMEMS system requires input from multiple independent elements to achieve its effect, and no studies hav...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/7979830 |
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| author | Jeffrey S. Tran Aaron M. Wolfson Daniel O’Brien Omid Yousefian David M. Shavelle |
| author_facet | Jeffrey S. Tran Aaron M. Wolfson Daniel O’Brien Omid Yousefian David M. Shavelle |
| author_sort | Jeffrey S. Tran |
| collection | DOAJ |
| description | Background. Hemodynamic-guided therapy using the CardioMEMS™ system has been shown to reduce heart failure hospitalization (HFH) in both clinical trials and real-world settings. However, the CardioMEMS system requires input from multiple independent elements to achieve its effect, and no studies have been done to investigate those elements. Consistent patient participation and health care provider participation are two of those key elements, and this study sought to assess how they affect HFHs. Methods. This was a single-center, retrospective cohort study of patients with the CardioMEMS sensor. The primary outcome was the number of HFH days patients experienced in the 1 year following CardioMEMS sensor implant. The primary independent variables were the average number of days between patient transmissions of data and the average number of days between health care provider reviews of those data. Covariates included patient demographics, medical comorbidities, history of HFHs, and initial pressure response to hemodynamic-guided therapy at 28 days after implant. Data were fit to a zero-inflated negative binomial regression. Results. Seventy-eight patients were included in the study. The mean age was 64 ± 15 years, 52 (67%) were male, and 58 (76%) had heart failure with reduced ejection fraction. During the study period, there were 538 cumulative HFH patient-days. Based on the regression model, there was an exponential relationship between HFH days and the mean number of days between patient transmissions (IRR = 1.74, 95% CI: 1.09–2.75, p=0.019). There was also an exponential relationship between HFH days and the mean number of days between health care provider reviews (IRR = 1.03, 95% CI: 1.01–1.05, p=0.013). Conclusions. This single-center study suggests that more frequent patient transmissions and health care provider reviews of the CardioMEMS system are associated with a decreased number of HFH days, but larger multicentered studies are required. Further systems-based analyses of the CardioMEMS system may be a useful approach to guiding effective use of the CardioMEMS device. |
| format | Article |
| id | doaj-art-612edf8f1b6742f7902a0081cfa26ae5 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-612edf8f1b6742f7902a0081cfa26ae52025-02-03T06:15:11ZengWileyCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/79798307979830A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure ManagementJeffrey S. Tran0Aaron M. Wolfson1Daniel O’Brien2Omid Yousefian3David M. Shavelle4Department of Internal Medicine, Keck School of Medicine of USC, Los Angeles 90033, CA, USADivision of Cardiovascular Medicine, University of Southern California, Los Angeles 90033, CA, USAKeck School of Medicine of USC, Los Angeles 90033, CA, USADepartment of Internal Medicine, Keck School of Medicine of USC, Los Angeles 90033, CA, USADivision of Cardiovascular Medicine, University of Southern California, Los Angeles 90033, CA, USABackground. Hemodynamic-guided therapy using the CardioMEMS™ system has been shown to reduce heart failure hospitalization (HFH) in both clinical trials and real-world settings. However, the CardioMEMS system requires input from multiple independent elements to achieve its effect, and no studies have been done to investigate those elements. Consistent patient participation and health care provider participation are two of those key elements, and this study sought to assess how they affect HFHs. Methods. This was a single-center, retrospective cohort study of patients with the CardioMEMS sensor. The primary outcome was the number of HFH days patients experienced in the 1 year following CardioMEMS sensor implant. The primary independent variables were the average number of days between patient transmissions of data and the average number of days between health care provider reviews of those data. Covariates included patient demographics, medical comorbidities, history of HFHs, and initial pressure response to hemodynamic-guided therapy at 28 days after implant. Data were fit to a zero-inflated negative binomial regression. Results. Seventy-eight patients were included in the study. The mean age was 64 ± 15 years, 52 (67%) were male, and 58 (76%) had heart failure with reduced ejection fraction. During the study period, there were 538 cumulative HFH patient-days. Based on the regression model, there was an exponential relationship between HFH days and the mean number of days between patient transmissions (IRR = 1.74, 95% CI: 1.09–2.75, p=0.019). There was also an exponential relationship between HFH days and the mean number of days between health care provider reviews (IRR = 1.03, 95% CI: 1.01–1.05, p=0.013). Conclusions. This single-center study suggests that more frequent patient transmissions and health care provider reviews of the CardioMEMS system are associated with a decreased number of HFH days, but larger multicentered studies are required. Further systems-based analyses of the CardioMEMS system may be a useful approach to guiding effective use of the CardioMEMS device.http://dx.doi.org/10.1155/2019/7979830 |
| spellingShingle | Jeffrey S. Tran Aaron M. Wolfson Daniel O’Brien Omid Yousefian David M. Shavelle A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management Cardiology Research and Practice |
| title | A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management |
| title_full | A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management |
| title_fullStr | A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management |
| title_full_unstemmed | A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management |
| title_short | A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management |
| title_sort | systems based analysis of the cardiomems hf sensor for chronic heart failure management |
| url | http://dx.doi.org/10.1155/2019/7979830 |
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