Systemic and cerebral iron homeostasis in ferritin knock-out mice.

Systemic and cerebral iron homeostasis in ferritin knock-out mice.

Ferritin, a 24-mer heteropolymer of heavy (H) and light (L) subunits, is the main cellular iron storage protein and plays a pivotal role in iron homeostasis by modulating free iron levels thus reducing radical-mediated damage. The H subunit has ferroxidase activity (converting Fe(II) to Fe(III)), wh...

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Main Authors: Wei Li, Holly J Garringer, Charles B Goodwin, Briana Richine, Anthony Acton, Natalia VanDuyn, Barry B Muhoberac, Jose Irimia-Dominguez, Rebecca J Chan, Munro Peacock, Richard Nass, Bernardino Ghetti, Ruben Vidal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117435&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117435&type=printable

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