A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients
[Objective] To investigate the risk factors of Clostridium difficile infection in elderly inpatients and provide the theoretical basis for the prevention and treatment of Clostridium difficile infection. [Methods] A total of 121 patients hospitalized in the Department of Geriatrics of Xijing Hospita...
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| Format: | Article |
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Editorial Office of International Journal of Geriatrics
2025-01-01
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| Series: | Guoji laonian yixue zazhi |
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| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.005&lang=en |
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| author | Yang Chen Yingjun Gong Cui Li Huan Li Jia Chen Hui Su Xiaoming Wang Xiaoxuan Ning |
| author_facet | Yang Chen Yingjun Gong Cui Li Huan Li Jia Chen Hui Su Xiaoming Wang Xiaoxuan Ning |
| author_sort | Yang Chen |
| collection | DOAJ |
| description | [Objective] To investigate the risk factors of Clostridium difficile infection in elderly inpatients and provide the theoretical basis for the prevention and treatment of Clostridium difficile infection. [Methods] A total of 121 patients hospitalized in the Department of Geriatrics of Xijing Hospital from November 2013 to June 2022 were selected for regression analysis and divided into a negative group(51 cases) and positive group(70 cases) according to the detection results of Clostridium difficile infection.The general data and clinical data of the two groups were compared and analyzed. [Results] The use rate of proton pump inhibitors, antibiotics and glucocorticoids in the positive group was higher than that in the negative group (P<0.05), the hemoglobin, alanine aminotransferase, aspartate aminotransferase, albumin, alkaline phosphatase and γ-glutamyl transferase and vitamin D levels in the positive group were lower than those in the negative group (P < 0.05), and the serum creatinine level in the positive group was higher than that in the negative group(P<0.05).Multivariate binary logistic regression analysis showed that hemoglobin, albumin, and vitamin D were protective factors for Clostridium difficile infection (P < 0.05), and antibiotic use and serum creatinine were independent risk factors for Clostridium difficile infection(P<0.05). [Conclusion] The incidence of Clostridium difficile infection is negatively correlated with vitamin D, albumin and hemoglobin levels, and positively correlated with antibiotic use and serum creatinine level.The above indicators need to be closely monitored in elderly hospitalized patients. |
| format | Article |
| id | doaj-art-611a7b49114248839b20def643ea8287 |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-611a7b49114248839b20def643ea82872025-01-21T02:59:39ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-01-01461202410.3969/j.issn.1674-7593.2025.01.005A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patientsYang Chen0Yingjun Gong1Cui Li2Huan Li3Jia Chen4Hui Su5Xiaoming Wang6Xiaoxuan Ning7Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032Department of Geriatric, Xijing Hospital, Air Force Military Medical University, Xi’an 710032[Objective] To investigate the risk factors of Clostridium difficile infection in elderly inpatients and provide the theoretical basis for the prevention and treatment of Clostridium difficile infection. [Methods] A total of 121 patients hospitalized in the Department of Geriatrics of Xijing Hospital from November 2013 to June 2022 were selected for regression analysis and divided into a negative group(51 cases) and positive group(70 cases) according to the detection results of Clostridium difficile infection.The general data and clinical data of the two groups were compared and analyzed. [Results] The use rate of proton pump inhibitors, antibiotics and glucocorticoids in the positive group was higher than that in the negative group (P<0.05), the hemoglobin, alanine aminotransferase, aspartate aminotransferase, albumin, alkaline phosphatase and γ-glutamyl transferase and vitamin D levels in the positive group were lower than those in the negative group (P < 0.05), and the serum creatinine level in the positive group was higher than that in the negative group(P<0.05).Multivariate binary logistic regression analysis showed that hemoglobin, albumin, and vitamin D were protective factors for Clostridium difficile infection (P < 0.05), and antibiotic use and serum creatinine were independent risk factors for Clostridium difficile infection(P<0.05). [Conclusion] The incidence of Clostridium difficile infection is negatively correlated with vitamin D, albumin and hemoglobin levels, and positively correlated with antibiotic use and serum creatinine level.The above indicators need to be closely monitored in elderly hospitalized patients.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.005&lang=enclostridium difficileinfectionrisk factors |
| spellingShingle | Yang Chen Yingjun Gong Cui Li Huan Li Jia Chen Hui Su Xiaoming Wang Xiaoxuan Ning A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients Guoji laonian yixue zazhi clostridium difficile infection risk factors |
| title | A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients |
| title_full | A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients |
| title_fullStr | A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients |
| title_full_unstemmed | A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients |
| title_short | A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients |
| title_sort | retrospective clinical study on the influencing factors of clostridium difficile infection in elderly patients |
| topic | clostridium difficile infection risk factors |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.005&lang=en |
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