Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity
Background. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). Methods. 69 patients with AICU, and 200 healthy subjects. R...
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/62489 |
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| author | Maria Luisa Pacor Gabriele Di Lorenzo Pasquale Mansueto Nicola Martinelli Maria Esposito-Pellitteri Paola Pradella Laura Uxa Gaetana Di Fede GiovamBattista Rini Roberto Corrocher |
| author_facet | Maria Luisa Pacor Gabriele Di Lorenzo Pasquale Mansueto Nicola Martinelli Maria Esposito-Pellitteri Paola Pradella Laura Uxa Gaetana Di Fede GiovamBattista Rini Roberto Corrocher |
| author_sort | Maria Luisa Pacor |
| collection | DOAJ |
| description | Background. HLA genes play a role in the predisposition of several diseases. The aim was to
analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). Methods. 69 patients with AICU, and 200 healthy subjects. Results. Subjects with HLA-B44 and HLA-Cw5 antigens were more
represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4,
and HLA-Cw7 antigen were more represented in control group than in patients with AICU.
Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower
risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences
were found between patients and controls as regards to HLA-DRB1* genotype. Conclusions. We
observed an association between some HLA class-I antigens and AICU. To the best of our
knowledge this is the first description of such association. |
| format | Article |
| id | doaj-art-60fe8f16a07e4a50b7be4bea6c0c7b79 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-60fe8f16a07e4a50b7be4bea6c0c7b792025-08-20T02:35:19ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/6248962489Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs HypersensitivityMaria Luisa Pacor0Gabriele Di Lorenzo1Pasquale Mansueto2Nicola Martinelli3Maria Esposito-Pellitteri4Paola Pradella5Laura Uxa6Gaetana Di Fede7GiovamBattista Rini8Roberto Corrocher9Dipartimento di Medicina Clinica e Sperimentale, Policlinico G.B. Rossi, Università di Verona, Piazzale Scuro, Verona 10-37134, ItalyDipartimento di Medicina Clinica e delle Patologie Emergenti, Università degli Studi di Palermo, Via del Vespro, Palermo 141-90127, ItalyDipartimento di Medicina Clinica e delle Patologie Emergenti, Università degli Studi di Palermo, Via del Vespro, Palermo 141-90127, ItalyDipartimento di Medicina Clinica e Sperimentale, Policlinico G.B. Rossi, Università di Verona, Piazzale Scuro, Verona 10-37134, ItalyDipartimento di Medicina Clinica e delle Patologie Emergenti, Università degli Studi di Palermo, Via del Vespro, Palermo 141-90127, ItalyServizio Immunotrasfusionale, Ospedale di Cattinara, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Trieste, Strada di Fiume, Trieste 447- 34149, ItalyServizio Immunotrasfusionale, Ospedale di Cattinara, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Trieste, Strada di Fiume, Trieste 447- 34149, ItalyDipartimento di Discipline Chirurgiche ed Oncologiche, Università degli Studi di Palermo, Via L. Giuffrè, Palermo 5 - 90127, ItalyDipartimento di Medicina Clinica e delle Patologie Emergenti, Università degli Studi di Palermo, Via del Vespro, Palermo 141-90127, ItalyDipartimento di Medicina Clinica e Sperimentale, Policlinico G.B. Rossi, Università di Verona, Piazzale Scuro, Verona 10-37134, ItalyBackground. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). Methods. 69 patients with AICU, and 200 healthy subjects. Results. Subjects with HLA-B44 and HLA-Cw5 antigens were more represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4, and HLA-Cw7 antigen were more represented in control group than in patients with AICU. Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences were found between patients and controls as regards to HLA-DRB1* genotype. Conclusions. We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first description of such association.http://dx.doi.org/10.1155/MI/2006/62489 |
| spellingShingle | Maria Luisa Pacor Gabriele Di Lorenzo Pasquale Mansueto Nicola Martinelli Maria Esposito-Pellitteri Paola Pradella Laura Uxa Gaetana Di Fede GiovamBattista Rini Roberto Corrocher Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity Mediators of Inflammation |
| title | Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity |
| title_full | Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity |
| title_fullStr | Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity |
| title_full_unstemmed | Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity |
| title_short | Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity |
| title_sort | relationship between human leucocyte antigen class i and class ii and chronic idiopathic urticaria associated with aspirin and or nsaids hypersensitivity |
| url | http://dx.doi.org/10.1155/MI/2006/62489 |
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