Relationship Between Human Leucocyte Antigen Class I and Class II and Chronic Idiopathic Urticaria Associated With Aspirin and/or NSAIDs Hypersensitivity
Background. HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). Methods. 69 patients with AICU, and 200 healthy subjects. R...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/62489 |
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| Summary: | Background. HLA genes play a role in the predisposition of several diseases. The aim was to
analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU). Methods. 69 patients with AICU, and 200 healthy subjects. Results. Subjects with HLA-B44 and HLA-Cw5 antigens were more
represented in patients with AICU than in control group. Subjects with HLA-A11, HLA-B13, HLACw4,
and HLA-Cw7 antigen were more represented in control group than in patients with AICU.
Multiple logistic regression demonstrated an association of HLA-Cw4 and HLA-Cw7 with a lower
risk of AICU, whereas carriers of HLA-B44 phenotype had a higher risk of AICU. No differences
were found between patients and controls as regards to HLA-DRB1* genotype. Conclusions. We
observed an association between some HLA class-I antigens and AICU. To the best of our
knowledge this is the first description of such association. |
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| ISSN: | 0962-9351 1466-1861 |