The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study
Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena....
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/787451 |
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| author | Delia Colombo Giovanni Abbruzzese Angelo Antonini Paolo Barone Gilberto Bellia Flavia Franconi Lucia Simoni Mahmood Attar Emanuela Zagni Shalom Haggiag Fabrizio Stocchi |
| author_facet | Delia Colombo Giovanni Abbruzzese Angelo Antonini Paolo Barone Gilberto Bellia Flavia Franconi Lucia Simoni Mahmood Attar Emanuela Zagni Shalom Haggiag Fabrizio Stocchi |
| author_sort | Delia Colombo |
| collection | DOAJ |
| description | Background. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, P=0.045) and the WOQ-19 analysis (72.5% versus 64.0%, P=0.034). In patients with WO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions. Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect. |
| format | Article |
| id | doaj-art-60eefe5e66dd48d3bd09e8d9b072d787 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-60eefe5e66dd48d3bd09e8d9b072d7872025-02-03T01:32:46ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/787451787451The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP StudyDelia Colombo0Giovanni Abbruzzese1Angelo Antonini2Paolo Barone3Gilberto Bellia4Flavia Franconi5Lucia Simoni6Mahmood Attar7Emanuela Zagni8Shalom Haggiag9Fabrizio Stocchi10Novartis Farma S.p.A., Origgio, Varese 21040, ItalyDepartment of Neurosciences, University of Genoa, Genoa 16132, ItalyDepartment of Parkinson’s Disease, IRCCS San Camillo, Venice 30126, ItalyScuola Medica Salernitana, Università degli Studi di Salerno, Salerno 84100, ItalyNovartis Farma S.p.A., Origgio, Varese 21040, ItalyDepartment of Biomedical Science, University of Sassari, Sassari 07100, ItalyMediData srl, Modena 41123, ItalyNovartis Farma S.p.A., Origgio, Varese 21040, ItalyNovartis Farma S.p.A., Origgio, Varese 21040, ItalyDepartment of Neurology, San Camillo-Forlanini Hospital, Rome 00151, ItalyDepartment of Neurology, Institute of Research and Medical Care, IRCCS San Raffaele, Rome 00163, ItalyBackground. The early detection of wearing-off in Parkinson disease (DEEP) observational study demonstrated that women with Parkinson’s disease (PD) carry an increased risk (80.1%) for wearing-off (WO). This post hoc analysis of DEEP study evaluates gender differences on WO and associated phenomena. Methods. Patients on dopaminergic treatment for ≥1 year were included in this multicenter observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as the use of the 19-item wearing-off questionnaire (WOQ-19); WO was defined for scores ≥2. Post hoc analyses were conducted to investigate gender difference for demographic and clinical features with respect to WO. Results. Of 617 patients enrolled, 236 were women and 381 were men. Prevalence of WO was higher among women, according to both neurologists’ judgment (61.9% versus 53.8%, P=0.045) and the WOQ-19 analysis (72.5% versus 64.0%, P=0.034). In patients with WO (WOQ-19), women experienced ≥1 motor symptom in 72.5% versus 64.0% in men and ≥1 nonmotor symptom in 44.5% versus 36.7%, in men. Conclusions. Our results suggest WO as more common among women, for both motor and nonmotor symptoms. Prospective studies are warranted to investigate this potential gender-effect.http://dx.doi.org/10.1155/2015/787451 |
| spellingShingle | Delia Colombo Giovanni Abbruzzese Angelo Antonini Paolo Barone Gilberto Bellia Flavia Franconi Lucia Simoni Mahmood Attar Emanuela Zagni Shalom Haggiag Fabrizio Stocchi The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study The Scientific World Journal |
| title | The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study |
| title_full | The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study |
| title_fullStr | The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study |
| title_full_unstemmed | The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study |
| title_short | The “Gender Factor” in Wearing-Off among Patients with Parkinson’s Disease: A Post Hoc Analysis of DEEP Study |
| title_sort | gender factor in wearing off among patients with parkinson s disease a post hoc analysis of deep study |
| url | http://dx.doi.org/10.1155/2015/787451 |
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