Multi-omics study on autophagic dysfunction molecular network in the pathogenesis of rheumatoid arthritis

Multi-omics study on autophagic dysfunction molecular network in the pathogenesis of rheumatoid arthritis

Abstract Background Autophagy is associated with the development of rheumatoid arthritis (RA), but its genetic pathological mechanisms remain incompletely understood. In this study, we employed summary-data-based Mendelian randomization (SMR) and co-localization analysis to systematically investigat...

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Bibliographic Details
Main Authors: Ping Jiang, Yichen Zhao, Youji Jia, Honghong Ma, Yajuan Guo, Wei Yan, Xiaobing Xi
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Rheumatoid arthritis
Mendelian randomization
Autophagy
Methylation
Gene expression
Protein
Online Access:https://doi.org/10.1186/s12967-025-06288-7
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