Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma
Neuroblastoma (NB) and malignant melanoma (MM), tumors of pediatric age and adulthood, respectively, share a common origin, both of them deriving from the neural crest cells. Although NB and MM have a different behavior, in respect to age of onset, primary tissue involvement and metastatic spread, t...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8097398 |
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| author | Fabio Morandi Francesco Frassoni Mirco Ponzoni Chiara Brignole |
| author_facet | Fabio Morandi Francesco Frassoni Mirco Ponzoni Chiara Brignole |
| author_sort | Fabio Morandi |
| collection | DOAJ |
| description | Neuroblastoma (NB) and malignant melanoma (MM), tumors of pediatric age and adulthood, respectively, share a common origin, both of them deriving from the neural crest cells. Although NB and MM have a different behavior, in respect to age of onset, primary tissue involvement and metastatic spread, the prognosis for high stage-affected patients is still poor, in spite of aggressive treatment strategies and the huge amount of new discovered biological knowledge. For these reasons researchers are continuously attempting to find out new treatment options, which in a near future could be translated to the clinical practice. In the last two decades, a strong effort has been spent in the field of translational research of immunotherapy which led to satisfactory results. Indeed, several immunotherapeutic clinical trials have been performed and some of them also resulted beneficial. Here, we summarize preclinical studies based on immunotherapeutic approaches applied in models of both NB and MM. |
| format | Article |
| id | doaj-art-60cd2796d191486693c1a4b8f813b79f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-60cd2796d191486693c1a4b8f813b79f2025-02-03T01:30:16ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/80973988097398Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant MelanomaFabio Morandi0Francesco Frassoni1Mirco Ponzoni2Chiara Brignole3Stem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16148 Genova, ItalyStem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16148 Genova, ItalyLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16148 Genova, ItalyLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16148 Genova, ItalyNeuroblastoma (NB) and malignant melanoma (MM), tumors of pediatric age and adulthood, respectively, share a common origin, both of them deriving from the neural crest cells. Although NB and MM have a different behavior, in respect to age of onset, primary tissue involvement and metastatic spread, the prognosis for high stage-affected patients is still poor, in spite of aggressive treatment strategies and the huge amount of new discovered biological knowledge. For these reasons researchers are continuously attempting to find out new treatment options, which in a near future could be translated to the clinical practice. In the last two decades, a strong effort has been spent in the field of translational research of immunotherapy which led to satisfactory results. Indeed, several immunotherapeutic clinical trials have been performed and some of them also resulted beneficial. Here, we summarize preclinical studies based on immunotherapeutic approaches applied in models of both NB and MM.http://dx.doi.org/10.1155/2018/8097398 |
| spellingShingle | Fabio Morandi Francesco Frassoni Mirco Ponzoni Chiara Brignole Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma Journal of Immunology Research |
| title | Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma |
| title_full | Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma |
| title_fullStr | Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma |
| title_full_unstemmed | Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma |
| title_short | Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma |
| title_sort | novel immunotherapeutic approaches for neuroblastoma and malignant melanoma |
| url | http://dx.doi.org/10.1155/2018/8097398 |
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