Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography
Background. Gastroesophageal reflux disease (GERD) is a common disease and a major upper gastrointestinal problem. The purpose of the present study is to evaluate the use of noninvasive 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) to detect gastroesophageal reflux esophagitis. M...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/702803 |
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| author | Min-Kuei Tsai Hueisch-Jy Ding Hsueh-Chou Lai Kuo-Yang Yen Chia-Ing Li Yu-Yi Lin Kai-Yuan Cheng Keh-Bin Wang Chia-Hung Kao |
| author_facet | Min-Kuei Tsai Hueisch-Jy Ding Hsueh-Chou Lai Kuo-Yang Yen Chia-Ing Li Yu-Yi Lin Kai-Yuan Cheng Keh-Bin Wang Chia-Hung Kao |
| author_sort | Min-Kuei Tsai |
| collection | DOAJ |
| description | Background. Gastroesophageal reflux disease (GERD) is a common disease and a major upper gastrointestinal problem. The purpose of the present study is to evaluate the use of noninvasive 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) to detect gastroesophageal reflux esophagitis. Materials and Methods. This is a retrospective study reviewing 408 healthy check-up subjects (169 females and 239 men), who underwent both FDG-PET and upper gastrointestinal endoscopy during September 2008 to December 2009. Quantitative analysis of FDG uptake in the distal part of the esophagus was performed by calculating the maximum standard uptake value (SUVmax). This indicated the degree of esophagitis. FDG-PET findings were compared with endoscopic (modified version of the Los Angeles classification) diagnoses as the gold standard. Results. The SUVmax ranged from 1.30 to 3.40 in normal subjects and from 1.30 to 4.00 in subjects with gastroesophageal reflux esophagitis. In the esophagitis group, the SUVmax was 2.13±0.42 in subjects with modified LA grade M, 2.21±0.45 in subjects with LA grade A, and 2.48±0.44 in subjects with LA grade B and C gastroesophageal reflux esophagitis. One-way ANOVA and post-hoc comparison with Bonferroni correction (P value = 0.003) identified statistical differences between the three groups. Conclusion. Noninvasive FDG-PET may be useful in the detection and evaluation of various degrees of gastroesophageal reflux esophagitis. |
| format | Article |
| id | doaj-art-60c87651395b4dbab5d30aa7e9fd8187 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-60c87651395b4dbab5d30aa7e9fd81872025-02-03T05:51:21ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/702803702803Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission TomographyMin-Kuei Tsai0Hueisch-Jy Ding1Hsueh-Chou Lai2Kuo-Yang Yen3Chia-Ing Li4Yu-Yi Lin5Kai-Yuan Cheng6Keh-Bin Wang7Chia-Hung Kao8Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 40601, TaiwanDepartment of Medical Imaging and Radiological Sciences, I-Shou University, Kaohsiung 84001, TaiwanDivision of Gastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung 404, TaiwanDepartment of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 404, TaiwanDepartment of Medical Research, China Medical University Hospital, Taichung 404, TaiwanDepartment of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 404, TaiwanDepartment of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung 40601, TaiwanDepartment of Nuclear Medicine, Kuang Tien General Hospital, Taichung 433, TaiwanDepartment of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 404, TaiwanBackground. Gastroesophageal reflux disease (GERD) is a common disease and a major upper gastrointestinal problem. The purpose of the present study is to evaluate the use of noninvasive 2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) to detect gastroesophageal reflux esophagitis. Materials and Methods. This is a retrospective study reviewing 408 healthy check-up subjects (169 females and 239 men), who underwent both FDG-PET and upper gastrointestinal endoscopy during September 2008 to December 2009. Quantitative analysis of FDG uptake in the distal part of the esophagus was performed by calculating the maximum standard uptake value (SUVmax). This indicated the degree of esophagitis. FDG-PET findings were compared with endoscopic (modified version of the Los Angeles classification) diagnoses as the gold standard. Results. The SUVmax ranged from 1.30 to 3.40 in normal subjects and from 1.30 to 4.00 in subjects with gastroesophageal reflux esophagitis. In the esophagitis group, the SUVmax was 2.13±0.42 in subjects with modified LA grade M, 2.21±0.45 in subjects with LA grade A, and 2.48±0.44 in subjects with LA grade B and C gastroesophageal reflux esophagitis. One-way ANOVA and post-hoc comparison with Bonferroni correction (P value = 0.003) identified statistical differences between the three groups. Conclusion. Noninvasive FDG-PET may be useful in the detection and evaluation of various degrees of gastroesophageal reflux esophagitis.http://dx.doi.org/10.1100/2012/702803 |
| spellingShingle | Min-Kuei Tsai Hueisch-Jy Ding Hsueh-Chou Lai Kuo-Yang Yen Chia-Ing Li Yu-Yi Lin Kai-Yuan Cheng Keh-Bin Wang Chia-Hung Kao Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography The Scientific World Journal |
| title | Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography |
| title_full | Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography |
| title_fullStr | Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography |
| title_full_unstemmed | Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography |
| title_short | Detection of Gastroesophageal Reflux Esophagitis Using 2-fluoro-2-deoxy-d-glucose Positron Emission Tomography |
| title_sort | detection of gastroesophageal reflux esophagitis using 2 fluoro 2 deoxy d glucose positron emission tomography |
| url | http://dx.doi.org/10.1100/2012/702803 |
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