The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/8352684 |
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| author | Sabrina Bimonte Antonio Barbieri Maddalena Leongito Giuseppe Palma Vitale del Vecchio Michela Falco Raffaele Palaia Vittorio Albino Mauro Piccirillo Alfonso Amore Antonella Petrillo Vincenza Granata Francesco Izzo |
| author_facet | Sabrina Bimonte Antonio Barbieri Maddalena Leongito Giuseppe Palma Vitale del Vecchio Michela Falco Raffaele Palaia Vittorio Albino Mauro Piccirillo Alfonso Amore Antonella Petrillo Vincenza Granata Francesco Izzo |
| author_sort | Sabrina Bimonte |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells. |
| format | Article |
| id | doaj-art-60c79c840905485ea59e20443c9afeab |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-60c79c840905485ea59e20443c9afeab2025-02-03T01:12:38ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/83526848352684The Role of miRNAs in the Regulation of Pancreatic Cancer Stem CellsSabrina Bimonte0Antonio Barbieri1Maddalena Leongito2Giuseppe Palma3Vitale del Vecchio4Michela Falco5Raffaele Palaia6Vittorio Albino7Mauro Piccirillo8Alfonso Amore9Antonella Petrillo10Vincenza Granata11Francesco Izzo12Division of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyAnimal Facility Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyAnimal Facility Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyAnimal Facility Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyAnimal Facility Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Radiology, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Radiology, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyDivision of Abdominal Surgical Oncology, Hepatobiliary Unit, National Cancer Institute “G. Pascale Foundation”, IRCCS, 80131 Naples, ItalyPancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.http://dx.doi.org/10.1155/2016/8352684 |
| spellingShingle | Sabrina Bimonte Antonio Barbieri Maddalena Leongito Giuseppe Palma Vitale del Vecchio Michela Falco Raffaele Palaia Vittorio Albino Mauro Piccirillo Alfonso Amore Antonella Petrillo Vincenza Granata Francesco Izzo The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells Stem Cells International |
| title | The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells |
| title_full | The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells |
| title_fullStr | The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells |
| title_full_unstemmed | The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells |
| title_short | The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells |
| title_sort | role of mirnas in the regulation of pancreatic cancer stem cells |
| url | http://dx.doi.org/10.1155/2016/8352684 |
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