Chronic Eosinophilic Leukemia Presenting as Cardiac Failure
Chronic eosinophilic leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia. Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems. This is of particular significance...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/7841310 |
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| author | Nii Boi-Doku Pepra-Ameyaw William Kwasi Ghunney Eugene Baafi Ampofo Edeghonghon Olayemi |
| author_facet | Nii Boi-Doku Pepra-Ameyaw William Kwasi Ghunney Eugene Baafi Ampofo Edeghonghon Olayemi |
| author_sort | Nii Boi-Doku Pepra-Ameyaw |
| collection | DOAJ |
| description | Chronic eosinophilic leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia. Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems. This is of particular significance in Sub-Saharan Africa where helminthic infections are a more prevalent cause of eosinophilia. To the best of our knowledge, we present the first reported case of CEL complicated by cardiac disease in a Ghanaian. He presented with a history of orthopnoea and dyspnoea on exertion, and examination revealed a pansystolic murmur over the mitral region and moderate splenomegaly. Good symptomatic control was achieved using hydroxyurea after which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine kinase inhibitor. Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage. |
| format | Article |
| id | doaj-art-60af0ee0c035404ba4dd45432c12de5f |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-60af0ee0c035404ba4dd45432c12de5f2025-02-03T05:58:32ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/7841310Chronic Eosinophilic Leukemia Presenting as Cardiac FailureNii Boi-Doku Pepra-Ameyaw0William Kwasi Ghunney1Eugene Baafi Ampofo2Edeghonghon Olayemi3Department of HaematologyGhana Institute of Clinical GeneticsNational Cardiothoracic CentreDepartment of HaematologyChronic eosinophilic leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia. Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems. This is of particular significance in Sub-Saharan Africa where helminthic infections are a more prevalent cause of eosinophilia. To the best of our knowledge, we present the first reported case of CEL complicated by cardiac disease in a Ghanaian. He presented with a history of orthopnoea and dyspnoea on exertion, and examination revealed a pansystolic murmur over the mitral region and moderate splenomegaly. Good symptomatic control was achieved using hydroxyurea after which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine kinase inhibitor. Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage.http://dx.doi.org/10.1155/2022/7841310 |
| spellingShingle | Nii Boi-Doku Pepra-Ameyaw William Kwasi Ghunney Eugene Baafi Ampofo Edeghonghon Olayemi Chronic Eosinophilic Leukemia Presenting as Cardiac Failure Case Reports in Hematology |
| title | Chronic Eosinophilic Leukemia Presenting as Cardiac Failure |
| title_full | Chronic Eosinophilic Leukemia Presenting as Cardiac Failure |
| title_fullStr | Chronic Eosinophilic Leukemia Presenting as Cardiac Failure |
| title_full_unstemmed | Chronic Eosinophilic Leukemia Presenting as Cardiac Failure |
| title_short | Chronic Eosinophilic Leukemia Presenting as Cardiac Failure |
| title_sort | chronic eosinophilic leukemia presenting as cardiac failure |
| url | http://dx.doi.org/10.1155/2022/7841310 |
| work_keys_str_mv | AT niiboidokupepraameyaw chroniceosinophilicleukemiapresentingascardiacfailure AT williamkwasighunney chroniceosinophilicleukemiapresentingascardiacfailure AT eugenebaafiampofo chroniceosinophilicleukemiapresentingascardiacfailure AT edeghonghonolayemi chroniceosinophilicleukemiapresentingascardiacfailure |