Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translation

Generative Adversarial Networks (GANs) are capturing the attention of peer researchers in paired or unpaired image-to-image translation applications, particularly in the domain of retinal image processing. Additionally, there are several effective image preprocessing techniques available that can si...

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Main Authors: Veena K.M., Veena Mayya, Rashmi Naveen Raj, Sulatha V. Bhandary, Uma Kulkarni
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computer Methods and Programs in Biomedicine Update
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666990025000035
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author Veena K.M.
Veena Mayya
Rashmi Naveen Raj
Sulatha V. Bhandary
Uma Kulkarni
author_facet Veena K.M.
Veena Mayya
Rashmi Naveen Raj
Sulatha V. Bhandary
Uma Kulkarni
author_sort Veena K.M.
collection DOAJ
description Generative Adversarial Networks (GANs) are capturing the attention of peer researchers in paired or unpaired image-to-image translation applications, particularly in the domain of retinal image processing. Additionally, there are several effective image preprocessing techniques available that can significantly improve the performance of GANs. This study examines the impact of five different image preprocessing techniques - Green Channel, CLAHE on Green Channel, CLAHE on RGB channels, Green Channel Gaussian Convolution, and RGB Gaussian Convolution - on five different GAN variants: CycleGAN, Pix2Pix GAN, CUT GAN, FastCut GAN, and NICE GAN. The study involved conducting 30 experiments to assess the performances of these GAN variants in the image-to-image translation of dual-mode retinal images. The evaluation utilized Frechet Inception Distance (FID) and Kernel Inception Distance (KID) metric scores to measure the performance of the GAN variants. The results demonstrated that the CycleGAN model achieved the best performance with CLAHE on RGB preprocessed images, achieving the lowest FID and KID scores of 103.49 and 0.038, respectively. This investigation underscores the significant potential of image preprocessing techniques in enhancing the performance of GANs in image translation applications.
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spelling doaj-art-60a9364775244c05b1c20b01ee6284b52025-01-31T05:12:36ZengElsevierComputer Methods and Programs in Biomedicine Update2666-99002025-01-017100179Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translationVeena K.M.0Veena Mayya1Rashmi Naveen Raj2Sulatha V. Bhandary3Uma Kulkarni4Department of Information & Communication Technology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaDepartment of Information & Communication Technology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; Corresponding authors.Department of Information & Communication Technology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India; Corresponding authors.Department of Ophthalmology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaDepartment of Ophthalmology, Yenepoya Medical College, Yenepoya (Deemed to be) University, Mangalore, 575018, Karnataka, IndiaGenerative Adversarial Networks (GANs) are capturing the attention of peer researchers in paired or unpaired image-to-image translation applications, particularly in the domain of retinal image processing. Additionally, there are several effective image preprocessing techniques available that can significantly improve the performance of GANs. This study examines the impact of five different image preprocessing techniques - Green Channel, CLAHE on Green Channel, CLAHE on RGB channels, Green Channel Gaussian Convolution, and RGB Gaussian Convolution - on five different GAN variants: CycleGAN, Pix2Pix GAN, CUT GAN, FastCut GAN, and NICE GAN. The study involved conducting 30 experiments to assess the performances of these GAN variants in the image-to-image translation of dual-mode retinal images. The evaluation utilized Frechet Inception Distance (FID) and Kernel Inception Distance (KID) metric scores to measure the performance of the GAN variants. The results demonstrated that the CycleGAN model achieved the best performance with CLAHE on RGB preprocessed images, achieving the lowest FID and KID scores of 103.49 and 0.038, respectively. This investigation underscores the significant potential of image preprocessing techniques in enhancing the performance of GANs in image translation applications.http://www.sciencedirect.com/science/article/pii/S2666990025000035Medical imagingClinical decision support systemsRetinal imagingFluorescein angiographyGenerative adversarial networksImage preprocessing
spellingShingle Veena K.M.
Veena Mayya
Rashmi Naveen Raj
Sulatha V. Bhandary
Uma Kulkarni
Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translation
Computer Methods and Programs in Biomedicine Update
Medical imaging
Clinical decision support systems
Retinal imaging
Fluorescein angiography
Generative adversarial networks
Image preprocessing
title Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translation
title_full Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translation
title_fullStr Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translation
title_full_unstemmed Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translation
title_short Analysis of preprocessing for Generative Adversarial Networks: A case study on color fundoscopy to fluorescein angiography image-to-image translation
title_sort analysis of preprocessing for generative adversarial networks a case study on color fundoscopy to fluorescein angiography image to image translation
topic Medical imaging
Clinical decision support systems
Retinal imaging
Fluorescein angiography
Generative adversarial networks
Image preprocessing
url http://www.sciencedirect.com/science/article/pii/S2666990025000035
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