Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study
Background. Colorectal signet ring cell carcinoma (SRCC) is a rare and distinct subtype of colorectal cancer (CRC), with extremely poor prognosis and aggressive tumor biological behavior. In this study, we aimed to analyze the clinicopathological characteristics and to identify the independent predi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/5393571 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551188357185536 |
|---|---|
| author | Wuguang Zhang Wenqian Gong Changhai Wu Mengting Li Xiaolong Tu |
| author_facet | Wuguang Zhang Wenqian Gong Changhai Wu Mengting Li Xiaolong Tu |
| author_sort | Wuguang Zhang |
| collection | DOAJ |
| description | Background. Colorectal signet ring cell carcinoma (SRCC) is a rare and distinct subtype of colorectal cancer (CRC), with extremely poor prognosis and aggressive tumor biological behavior. In this study, we aimed to analyze the clinicopathological characteristics and to identify the independent predictors of long-time survivors (LTSs) of nonmetastatic colorectal SRCC. Methods. Patients diagnosed with nonmetastatic colorectal SRCC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We compared and analyzed the clinicopathological characteristics between LTSs (patients survived over 5 years) and non-LTSs (patients survived of or less than 5 years). Afterwards, multivariate logistic regression analysis was used to identify independent predictors of LTSs, which were further used to construct a nomogram model to predict the probability of being LTSs. Results. We enrolled 2050 patients with nonmetastatic colorectal SRCC, consisting of 1441 non-LTSs and 609 LTSs. Multivariate logistic regression analysis revealed that race, marital status, tumor infiltration, lymph node involvement, and primary tumor treatment were independent predictors of LTSs. In addition, these five parameters were incorporated into a nomogram model to predict the probability of being LTSs. In terms of the model performance, the calibration curve revealed good agreement between observed and predicted probability of LTSs, and receiving operator characteristic curve showed acceptable discriminative capacity in the training and validation cohorts. Conclusion. Collectively, we analyzed and profiled the clinicopathological characteristics of LTSs in patients with nonmetastatic colorectal SRCC. Race, marital status, T stage, N stage, and primary tumor treatment were independent predictors of LTSs. |
| format | Article |
| id | doaj-art-60a72cb5f57e4d62b90bc62d1a6b34a9 |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-60a72cb5f57e4d62b90bc62d1a6b34a92025-02-03T06:04:39ZengWileyGastroenterology Research and Practice1687-630X2022-01-01202210.1155/2022/5393571Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based StudyWuguang Zhang0Wenqian Gong1Changhai Wu2Mengting Li3Xiaolong Tu4Oncology Department of Integrated Traditional Chinese and Western MedicineTraditional Chinese Medicine DepartmentDepartment of AcupunctureDepartment of GastroenterologyDepartment of OncologyBackground. Colorectal signet ring cell carcinoma (SRCC) is a rare and distinct subtype of colorectal cancer (CRC), with extremely poor prognosis and aggressive tumor biological behavior. In this study, we aimed to analyze the clinicopathological characteristics and to identify the independent predictors of long-time survivors (LTSs) of nonmetastatic colorectal SRCC. Methods. Patients diagnosed with nonmetastatic colorectal SRCC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We compared and analyzed the clinicopathological characteristics between LTSs (patients survived over 5 years) and non-LTSs (patients survived of or less than 5 years). Afterwards, multivariate logistic regression analysis was used to identify independent predictors of LTSs, which were further used to construct a nomogram model to predict the probability of being LTSs. Results. We enrolled 2050 patients with nonmetastatic colorectal SRCC, consisting of 1441 non-LTSs and 609 LTSs. Multivariate logistic regression analysis revealed that race, marital status, tumor infiltration, lymph node involvement, and primary tumor treatment were independent predictors of LTSs. In addition, these five parameters were incorporated into a nomogram model to predict the probability of being LTSs. In terms of the model performance, the calibration curve revealed good agreement between observed and predicted probability of LTSs, and receiving operator characteristic curve showed acceptable discriminative capacity in the training and validation cohorts. Conclusion. Collectively, we analyzed and profiled the clinicopathological characteristics of LTSs in patients with nonmetastatic colorectal SRCC. Race, marital status, T stage, N stage, and primary tumor treatment were independent predictors of LTSs.http://dx.doi.org/10.1155/2022/5393571 |
| spellingShingle | Wuguang Zhang Wenqian Gong Changhai Wu Mengting Li Xiaolong Tu Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study Gastroenterology Research and Practice |
| title | Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study |
| title_full | Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study |
| title_fullStr | Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study |
| title_full_unstemmed | Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study |
| title_short | Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study |
| title_sort | predictors of long time survivors in nonmetastatic colorectal signet ring cell carcinoma a large population based study |
| url | http://dx.doi.org/10.1155/2022/5393571 |
| work_keys_str_mv | AT wuguangzhang predictorsoflongtimesurvivorsinnonmetastaticcolorectalsignetringcellcarcinomaalargepopulationbasedstudy AT wenqiangong predictorsoflongtimesurvivorsinnonmetastaticcolorectalsignetringcellcarcinomaalargepopulationbasedstudy AT changhaiwu predictorsoflongtimesurvivorsinnonmetastaticcolorectalsignetringcellcarcinomaalargepopulationbasedstudy AT mengtingli predictorsoflongtimesurvivorsinnonmetastaticcolorectalsignetringcellcarcinomaalargepopulationbasedstudy AT xiaolongtu predictorsoflongtimesurvivorsinnonmetastaticcolorectalsignetringcellcarcinomaalargepopulationbasedstudy |