Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study
Background. Besides lipid-lowering effect of statins, they have been shown to have nonlipid lowering effects, such as improving bone health. An improvement in bone mineral density (BMD) has been indicated in some studies after the use of statins, in addition to an increase in 25-hydroxyvitamin D (25...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2014/468397 |
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| author | Abrar Thabit Abdullah Alhifany Razan Alsheikh Sameh Namnqani Ameen Al-Mohammadi Soha Elmorsy Mohammed Qari Mohammed Ardawi |
| author_facet | Abrar Thabit Abdullah Alhifany Razan Alsheikh Sameh Namnqani Ameen Al-Mohammadi Soha Elmorsy Mohammed Qari Mohammed Ardawi |
| author_sort | Abrar Thabit |
| collection | DOAJ |
| description | Background. Besides lipid-lowering effect of statins, they have been shown to have nonlipid lowering effects, such as improving bone health. An improvement in bone mineral density (BMD) has been indicated in some studies after the use of statins, in addition to an increase in 25-hydroxyvitamin D (25OHD) level. The aim of this study is to explore the association between statins and bone health taking into consideration 25OHD level and BMD. Methods. This is a randomized, cross-sectional comparative study. Subjects were divided into two groups, hypercholesterolemic participants taking simvastatin or atorvastatin as the study group and a matched control group not taking statins. All participants were assessed for serum 25OHD and BMD at lumbar spine and femoral neck. Results. A total of 114 participants were included in the study, 57 participants in each group. Results of serum 25OHD showed no significant difference between study and control groups (P=0.47), while BMD results of lumbar spine and femoral neck showed significant difference (P=0.05 and 0.03, resp.). Conclusion. Simvastatin and atorvastatin, at any dose for duration of more than one year, have no additive effect on 25OHD level but have a positive effect on the BMD. |
| format | Article |
| id | doaj-art-60a323dc2f4e4f9a8ee97aca818ab682 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-60a323dc2f4e4f9a8ee97aca818ab6822025-02-03T06:13:07ZengWileyJournal of Osteoporosis2090-80592042-00642014-01-01201410.1155/2014/468397468397Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional StudyAbrar Thabit0Abdullah Alhifany1Razan Alsheikh2Sameh Namnqani3Ameen Al-Mohammadi4Soha Elmorsy5Mohammed Qari6Mohammed Ardawi7Clinical Pharmacy Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254, Saudi ArabiaClinical Pharmacy Department, Faculty of Pharmacy, Umm Al-Qura University, Makkah 24243, Saudi ArabiaClinical Pharmacy Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254, Saudi ArabiaKing Abdullah Medical City, Makkah 24246, Saudi ArabiaClinical Pharmacy Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254, Saudi ArabiaKing Abdullah Medical City, Makkah 24246, Saudi ArabiaCenter of Excellence for Osteoporosis Research, King Abdulaziz University, Jeddah 22254, Saudi ArabiaCenter of Excellence for Osteoporosis Research, King Abdulaziz University, Jeddah 22254, Saudi ArabiaBackground. Besides lipid-lowering effect of statins, they have been shown to have nonlipid lowering effects, such as improving bone health. An improvement in bone mineral density (BMD) has been indicated in some studies after the use of statins, in addition to an increase in 25-hydroxyvitamin D (25OHD) level. The aim of this study is to explore the association between statins and bone health taking into consideration 25OHD level and BMD. Methods. This is a randomized, cross-sectional comparative study. Subjects were divided into two groups, hypercholesterolemic participants taking simvastatin or atorvastatin as the study group and a matched control group not taking statins. All participants were assessed for serum 25OHD and BMD at lumbar spine and femoral neck. Results. A total of 114 participants were included in the study, 57 participants in each group. Results of serum 25OHD showed no significant difference between study and control groups (P=0.47), while BMD results of lumbar spine and femoral neck showed significant difference (P=0.05 and 0.03, resp.). Conclusion. Simvastatin and atorvastatin, at any dose for duration of more than one year, have no additive effect on 25OHD level but have a positive effect on the BMD.http://dx.doi.org/10.1155/2014/468397 |
| spellingShingle | Abrar Thabit Abdullah Alhifany Razan Alsheikh Sameh Namnqani Ameen Al-Mohammadi Soha Elmorsy Mohammed Qari Mohammed Ardawi Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study Journal of Osteoporosis |
| title | Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study |
| title_full | Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study |
| title_fullStr | Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study |
| title_full_unstemmed | Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study |
| title_short | Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study |
| title_sort | effect of simvastatin and atorvastatin on serum vitamin d and bone mineral density in hypercholesterolemic patients a cross sectional study |
| url | http://dx.doi.org/10.1155/2014/468397 |
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