Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/425410 |
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| author | Ömür Gökmen Sevindik İnci Alacacıoğlu Abdullah Katgı Şerife Medeni Solmaz Celal Acar Özden Pişkin Mehmet Ali Özcan Fatih Demirkan Bülent Ündar Güner Hayri Özsan |
| author_facet | Ömür Gökmen Sevindik İnci Alacacıoğlu Abdullah Katgı Şerife Medeni Solmaz Celal Acar Özden Pişkin Mehmet Ali Özcan Fatih Demirkan Bülent Ündar Güner Hayri Özsan |
| author_sort | Ömür Gökmen Sevindik |
| collection | DOAJ |
| description | Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation. |
| format | Article |
| id | doaj-art-6097feba29e24b9cae7ac56646388297 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-6097feba29e24b9cae7ac566463882972025-02-03T01:03:20ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/425410425410Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell TransplantationÖmür Gökmen Sevindik0İnci Alacacıoğlu1Abdullah Katgı2Şerife Medeni Solmaz3Celal Acar4Özden Pişkin5Mehmet Ali Özcan6Fatih Demirkan7Bülent Ündar8Güner Hayri Özsan9Department of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyDepartment of Hematology, Dokuz Eylül University, 35340 Izmir, TurkeyTransplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation.http://dx.doi.org/10.1155/2015/425410 |
| spellingShingle | Ömür Gökmen Sevindik İnci Alacacıoğlu Abdullah Katgı Şerife Medeni Solmaz Celal Acar Özden Pişkin Mehmet Ali Özcan Fatih Demirkan Bülent Ündar Güner Hayri Özsan Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation Case Reports in Hematology |
| title | Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation |
| title_full | Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation |
| title_fullStr | Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation |
| title_full_unstemmed | Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation |
| title_short | Renal and Neurological Response with Eculizumab in a Patient with Transplant Associated Thrombotic Microangiopathy after Allogeneic Hematopoietic Progenitor Cell Transplantation |
| title_sort | renal and neurological response with eculizumab in a patient with transplant associated thrombotic microangiopathy after allogeneic hematopoietic progenitor cell transplantation |
| url | http://dx.doi.org/10.1155/2015/425410 |
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