Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature
Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/8247960 |
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| author | Kyle Kreitman Satheesh P. Nair Jiten P. Kothadia |
| author_facet | Kyle Kreitman Satheesh P. Nair Jiten P. Kothadia |
| author_sort | Kyle Kreitman |
| collection | DOAJ |
| description | Crizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. The medication was discontinued, and she was treated with N-acetylcysteine for seven days. Her liver function tests returned to normal limits after 26 days after admission. The precise mechanism and risk factors of crizotinib-induced hepatotoxicity remain unknown. Physicians should be aware of the potentially lethal side effect caused by crizotinib. |
| format | Article |
| id | doaj-art-609583509748415baa556f78896c3b7c |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-609583509748415baa556f78896c3b7c2025-02-03T06:06:43ZengWileyCase Reports in Hepatology2090-65872090-65952020-01-01202010.1155/2020/82479608247960Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of LiteratureKyle Kreitman0Satheesh P. Nair1Jiten P. Kothadia2MUH James D. Eason Transplant Institute, University of Tennessee Health Sciences Center, 1265 Union Avenue, 4 Shorb Tower, Memphis, TN 38104, USAMUH James D. Eason Transplant Institute, University of Tennessee Health Sciences Center, 1265 Union Avenue, 4 Shorb Tower, Memphis, TN 38104, USAMUH James D. Eason Transplant Institute, University of Tennessee Health Sciences Center, 1265 Union Avenue, 4 Shorb Tower, Memphis, TN 38104, USACrizotinib is a first-line tyrosine kinase inhibitor used for the treatment of metastatic lung cancer. Crizotinib-induced hepatotoxicity is a rare event. We report a case of a 46-year-old female with a history of metastatic lung cancer who presented with acute liver failure after being on crizotinib for two months. The medication was discontinued, and she was treated with N-acetylcysteine for seven days. Her liver function tests returned to normal limits after 26 days after admission. The precise mechanism and risk factors of crizotinib-induced hepatotoxicity remain unknown. Physicians should be aware of the potentially lethal side effect caused by crizotinib.http://dx.doi.org/10.1155/2020/8247960 |
| spellingShingle | Kyle Kreitman Satheesh P. Nair Jiten P. Kothadia Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature Case Reports in Hepatology |
| title | Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature |
| title_full | Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature |
| title_fullStr | Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature |
| title_full_unstemmed | Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature |
| title_short | Successful Treatment of Crizotinib-Induced Fulminant Liver Failure: A Case Report and Review of Literature |
| title_sort | successful treatment of crizotinib induced fulminant liver failure a case report and review of literature |
| url | http://dx.doi.org/10.1155/2020/8247960 |
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