Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes
In this experiment, the excellent coordination ability of sulfur-containing ligands was utilized. Diphenylacetyl disulfide and 3,3′-diaminodiphenyl sulfone were selected as ligands, and Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O, Ni(NO<sub>3</sub>)...
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2025-01-01
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| author | Yanting Yang Danqin Li Mei Luo |
| author_facet | Yanting Yang Danqin Li Mei Luo |
| author_sort | Yanting Yang |
| collection | DOAJ |
| description | In this experiment, the excellent coordination ability of sulfur-containing ligands was utilized. Diphenylacetyl disulfide and 3,3′-diaminodiphenyl sulfone were selected as ligands, and Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O, Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O and ZnCl<sub>2</sub> were reacted under one-pot conditions to synthesize three mononuclear complexes: [C<sub>4</sub>H<sub>18</sub>CuO<sub>12</sub>S<sub>2</sub>](I), [C<sub>12</sub>H<sub>18</sub>N<sub>4</sub>NiO<sub>11</sub>S](II) and [C<sub>24</sub>H<sub>24</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>4</sub>S<sub>2</sub>Zn](III). Complex (I) belongs to the orthorhombic crystal system with space group Pbca, while complexes (II) and (III) belong to the monoclinic crystal system with space groups P21/n and P2/n. The crystal structure of the complex was determined using X-ray diffraction (XRD). The structure of the complex was analyzed using infrared Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV–Vis), nuclear magnetic resonance (NMR), and electrospray mass spectrometry (ESI-MS), and the thermal stability and composition of the complex were detected via thermogravimetry (TGA). In terms of application, the biological activity of complexes (I)–(III) in human cancer cell lines (lung cancer A549, liver cancer SMMC-7721, breast cancer MDA-MB-231, and colon cancer SW480) was tested using the MTS method. The results showed that complex (II) had a good inhibitory effect on breast cancer MDA-MB-231. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Inorganics |
| spelling | doaj-art-608401e1152d4eddaa83a201deadc9d02025-01-24T13:35:31ZengMDPI AGInorganics2304-67402025-01-011312610.3390/inorganics13010026Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal ComplexesYanting Yang0Danqin Li1Mei Luo2Department of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230002, ChinaDepartment of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230002, ChinaDepartment of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230002, ChinaIn this experiment, the excellent coordination ability of sulfur-containing ligands was utilized. Diphenylacetyl disulfide and 3,3′-diaminodiphenyl sulfone were selected as ligands, and Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O, Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O and ZnCl<sub>2</sub> were reacted under one-pot conditions to synthesize three mononuclear complexes: [C<sub>4</sub>H<sub>18</sub>CuO<sub>12</sub>S<sub>2</sub>](I), [C<sub>12</sub>H<sub>18</sub>N<sub>4</sub>NiO<sub>11</sub>S](II) and [C<sub>24</sub>H<sub>24</sub>Cl<sub>2</sub>N<sub>4</sub>O<sub>4</sub>S<sub>2</sub>Zn](III). Complex (I) belongs to the orthorhombic crystal system with space group Pbca, while complexes (II) and (III) belong to the monoclinic crystal system with space groups P21/n and P2/n. The crystal structure of the complex was determined using X-ray diffraction (XRD). The structure of the complex was analyzed using infrared Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV–Vis), nuclear magnetic resonance (NMR), and electrospray mass spectrometry (ESI-MS), and the thermal stability and composition of the complex were detected via thermogravimetry (TGA). In terms of application, the biological activity of complexes (I)–(III) in human cancer cell lines (lung cancer A549, liver cancer SMMC-7721, breast cancer MDA-MB-231, and colon cancer SW480) was tested using the MTS method. The results showed that complex (II) had a good inhibitory effect on breast cancer MDA-MB-231.https://www.mdpi.com/2304-6740/13/1/26one-pot methodcomplexcrystal structurecytotoxicity |
| spellingShingle | Yanting Yang Danqin Li Mei Luo Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes Inorganics one-pot method complex crystal structure cytotoxicity |
| title | Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes |
| title_full | Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes |
| title_fullStr | Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes |
| title_full_unstemmed | Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes |
| title_short | Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes |
| title_sort | synthesis characterization and cytotoxicity research of sulfur containing metal complexes |
| topic | one-pot method complex crystal structure cytotoxicity |
| url | https://www.mdpi.com/2304-6740/13/1/26 |
| work_keys_str_mv | AT yantingyang synthesischaracterizationandcytotoxicityresearchofsulfurcontainingmetalcomplexes AT danqinli synthesischaracterizationandcytotoxicityresearchofsulfurcontainingmetalcomplexes AT meiluo synthesischaracterizationandcytotoxicityresearchofsulfurcontainingmetalcomplexes |