A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations
The comparative cytotoxic evaluation of two monomers, diacetone acrylamide (DA) and acrylamide (AA) used in holographic photopolymer formulations, is reported. Two normal cell lines were used: BEAS-2B and HaCaT. Cellular viability was assessed using the MTT assay for three different exposure times....
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2013/564319 |
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| author | Dervil Cody Alan Casey Izabela Naydenova Emilia Mihaylova |
| author_facet | Dervil Cody Alan Casey Izabela Naydenova Emilia Mihaylova |
| author_sort | Dervil Cody |
| collection | DOAJ |
| description | The comparative cytotoxic evaluation of two monomers, diacetone acrylamide (DA) and acrylamide (AA) used in holographic photopolymer formulations, is reported. Two normal cell lines were used: BEAS-2B and HaCaT. Cellular viability was assessed using the MTT assay for three different exposure times. A difference of two orders of magnitude is observed in the lethal dose (LD50) concentrations of the two monomers. Diacetone acrylamide exhibits a significantly lower toxicity profile in comparison to acrylamide at all exposure times. This result justifies the replacement of acrylamide with diacetone acrylamide in the photopolymer formulation, with the view to reducing occupational hazard risks for large-scale holographic device fabrication. A comparative study investigating the holographic recording ability of the two photopolymers in transmission mode showed that the DA photopolymer is capable of reaching refractive index modulation values of 3.3×10-3, which is 80% of the refractive index modulation achieved by the AA photopolymer. This makes the DA-based photopolymers suitable for a wide range of applications. |
| format | Article |
| id | doaj-art-607c01912bcd4ebe80c7d90fea7e272a |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-607c01912bcd4ebe80c7d90fea7e272a2025-02-03T06:15:12ZengWileyInternational Journal of Polymer Science1687-94221687-94302013-01-01201310.1155/2013/564319564319A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer FormulationsDervil Cody0Alan Casey1Izabela Naydenova2Emilia Mihaylova3Centre for Industrial and Engineering Optics, Dublin Institute of Technology, Dublin 8, IrelandSchool of Physics, College of Sciences and Health, Dublin Institute of Technology, Dublin 8, IrelandCentre for Industrial and Engineering Optics, Dublin Institute of Technology, Dublin 8, IrelandCentre for Industrial and Engineering Optics, Dublin Institute of Technology, Dublin 8, IrelandThe comparative cytotoxic evaluation of two monomers, diacetone acrylamide (DA) and acrylamide (AA) used in holographic photopolymer formulations, is reported. Two normal cell lines were used: BEAS-2B and HaCaT. Cellular viability was assessed using the MTT assay for three different exposure times. A difference of two orders of magnitude is observed in the lethal dose (LD50) concentrations of the two monomers. Diacetone acrylamide exhibits a significantly lower toxicity profile in comparison to acrylamide at all exposure times. This result justifies the replacement of acrylamide with diacetone acrylamide in the photopolymer formulation, with the view to reducing occupational hazard risks for large-scale holographic device fabrication. A comparative study investigating the holographic recording ability of the two photopolymers in transmission mode showed that the DA photopolymer is capable of reaching refractive index modulation values of 3.3×10-3, which is 80% of the refractive index modulation achieved by the AA photopolymer. This makes the DA-based photopolymers suitable for a wide range of applications.http://dx.doi.org/10.1155/2013/564319 |
| spellingShingle | Dervil Cody Alan Casey Izabela Naydenova Emilia Mihaylova A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations International Journal of Polymer Science |
| title | A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations |
| title_full | A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations |
| title_fullStr | A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations |
| title_full_unstemmed | A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations |
| title_short | A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations |
| title_sort | comparative cytotoxic evaluation of acrylamide and diacetone acrylamide to investigate their suitability for holographic photopolymer formulations |
| url | http://dx.doi.org/10.1155/2013/564319 |
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