KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus
Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/908152 |
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| author | Polin Haghvirdizadeh Zahurin Mohamed Nor Azizan Abdullah Pantea Haghvirdizadeh Monir Sadat Haerian Batoul Sadat Haerian |
| author_facet | Polin Haghvirdizadeh Zahurin Mohamed Nor Azizan Abdullah Pantea Haghvirdizadeh Monir Sadat Haerian Batoul Sadat Haerian |
| author_sort | Polin Haghvirdizadeh |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactions are involved in the insulin secretion pathway. Insulin secretion is mediated through the ATP-sensitive potassium (KATP) channel in pancreatic beta cells. This channel is a heteromeric protein, composed of four inward-rectifier potassium ion channel (Kir6.2) tetramers, which form the pore of the KATP channel, as well as sulfonylurea receptor 1 subunits surrounding the pore. Kir6.2 is encoded by the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) gene, a member of the potassium channel genes. Numerous studies have reported the involvement of single nucleotide polymorphisms of the KCNJ11 gene and their interactions in the susceptibility to DM. This review discusses the current evidence for the contribution of common KCNJ11 genetic variants to the development of DM. Future studies should concentrate on understanding the exact role played by these risk variants in the development of DM. |
| format | Article |
| id | doaj-art-605908e505e04fda95ce030cbfe84f40 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-605908e505e04fda95ce030cbfe84f402025-02-03T01:30:56ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/908152908152KCNJ11: Genetic Polymorphisms and Risk of Diabetes MellitusPolin Haghvirdizadeh0Zahurin Mohamed1Nor Azizan Abdullah2Pantea Haghvirdizadeh3Monir Sadat Haerian4Batoul Sadat Haerian5Pharmacogenomics Lab, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaPharmacogenomics Lab, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Biology, Faculty of Science, Azad University, Tehran, IranShahid Beheshti University of Medical Sciences, P.O. Box 19395-4763, Tehran, IranPharmacogenomics Lab, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDiabetes mellitus (DM) is a major worldwide health problem and its prevalence has been rapidly increasing in the last century. It is caused by defects in insulin secretion or insulin action or both, leading to hyperglycemia. Of the various types of DM, type 2 occurs most frequently. Multiple genes and their interactions are involved in the insulin secretion pathway. Insulin secretion is mediated through the ATP-sensitive potassium (KATP) channel in pancreatic beta cells. This channel is a heteromeric protein, composed of four inward-rectifier potassium ion channel (Kir6.2) tetramers, which form the pore of the KATP channel, as well as sulfonylurea receptor 1 subunits surrounding the pore. Kir6.2 is encoded by the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) gene, a member of the potassium channel genes. Numerous studies have reported the involvement of single nucleotide polymorphisms of the KCNJ11 gene and their interactions in the susceptibility to DM. This review discusses the current evidence for the contribution of common KCNJ11 genetic variants to the development of DM. Future studies should concentrate on understanding the exact role played by these risk variants in the development of DM.http://dx.doi.org/10.1155/2015/908152 |
| spellingShingle | Polin Haghvirdizadeh Zahurin Mohamed Nor Azizan Abdullah Pantea Haghvirdizadeh Monir Sadat Haerian Batoul Sadat Haerian KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus Journal of Diabetes Research |
| title | KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus |
| title_full | KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus |
| title_fullStr | KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus |
| title_full_unstemmed | KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus |
| title_short | KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus |
| title_sort | kcnj11 genetic polymorphisms and risk of diabetes mellitus |
| url | http://dx.doi.org/10.1155/2015/908152 |
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