The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation
Lidocaine, a common local anesthetic drug, has anti-inflammatory effects. It has demonstrated a protective effect in mice from septic peritonitis. However, it is unknown whether lidocaine has effects on high mobility group box 1 (HMGB1), a key mediator of inflammation. In this study, we investigate...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/570370 |
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| author | Huan-Liang Wang Yan-Qiu Xing Ying-Xue Xu Fei Rong Wei-Fu Lei Wen-Hua Zhang |
| author_facet | Huan-Liang Wang Yan-Qiu Xing Ying-Xue Xu Fei Rong Wei-Fu Lei Wen-Hua Zhang |
| author_sort | Huan-Liang Wang |
| collection | DOAJ |
| description | Lidocaine, a common local anesthetic drug, has anti-inflammatory effects. It has demonstrated a protective effect in mice from septic peritonitis. However, it is unknown whether lidocaine has effects on high mobility group box 1 (HMGB1), a key mediator of inflammation. In this study, we investigated the effect of lidocaine treatment on serum HMGB1 level and HMGB1 expression in liver, lungs, kidneys, and ileum in septic rats induced by cecal ligation and puncture (CLP). We found that acute organ injury induced by CLP was mitigated by lidocaine treatment and organ function was significantly improved. The data also demonstrated that lidocaine treatment raised the survival of septic rats. Furthermore, lidocaine suppressed the level of serum HMGB1, the expression of HMGB1, and the activation of NF-κB p65 in liver, kidneys, lungs, and ileum. Taken together, these results suggest that lidocaine treatment exerts its protective effection on CLP-induced septic rats. The mechanism was relative to the inhibitory effect of lidocaine on the mRNA expression level of HMGB1 in multiple organs, release of HMGB1 to plasma, and activation of NF-κB. |
| format | Article |
| id | doaj-art-604d4570816343e9a329e76190162a30 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-604d4570816343e9a329e76190162a302025-02-03T01:09:39ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/570370570370The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB ActivationHuan-Liang Wang0Yan-Qiu Xing1Ying-Xue Xu2Fei Rong3Wei-Fu Lei4Wen-Hua Zhang5Department of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, ChinaDepartment of Cardiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, ChinaDepartment of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, ChinaDepartment of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, ChinaDepartment of Anesthesiology, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, ChinaDepartment of Neurosurgery, Qilu Hospital, Shandong University, No. 107 Wenhuaxi Road, Jinan, Shandong 250012, ChinaLidocaine, a common local anesthetic drug, has anti-inflammatory effects. It has demonstrated a protective effect in mice from septic peritonitis. However, it is unknown whether lidocaine has effects on high mobility group box 1 (HMGB1), a key mediator of inflammation. In this study, we investigated the effect of lidocaine treatment on serum HMGB1 level and HMGB1 expression in liver, lungs, kidneys, and ileum in septic rats induced by cecal ligation and puncture (CLP). We found that acute organ injury induced by CLP was mitigated by lidocaine treatment and organ function was significantly improved. The data also demonstrated that lidocaine treatment raised the survival of septic rats. Furthermore, lidocaine suppressed the level of serum HMGB1, the expression of HMGB1, and the activation of NF-κB p65 in liver, kidneys, lungs, and ileum. Taken together, these results suggest that lidocaine treatment exerts its protective effection on CLP-induced septic rats. The mechanism was relative to the inhibitory effect of lidocaine on the mRNA expression level of HMGB1 in multiple organs, release of HMGB1 to plasma, and activation of NF-κB.http://dx.doi.org/10.1155/2013/570370 |
| spellingShingle | Huan-Liang Wang Yan-Qiu Xing Ying-Xue Xu Fei Rong Wei-Fu Lei Wen-Hua Zhang The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation Mediators of Inflammation |
| title | The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation |
| title_full | The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation |
| title_fullStr | The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation |
| title_full_unstemmed | The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation |
| title_short | The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation |
| title_sort | protective effect of lidocaine on septic rats via the inhibition of high mobility group box 1 expression and nf κb activation |
| url | http://dx.doi.org/10.1155/2013/570370 |
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