Control of Physical and Biochemical Parameters Influencing Exogeneous Cargo Protein Association to Extracellular Vesicles Using Lipid Anchors Enables High Loading and Effective Intracellular Delivery

Control of Physical and Biochemical Parameters Influencing Exogeneous Cargo Protein Association to Extracellular Vesicles Using Lipid Anchors Enables High Loading and Effective Intracellular Delivery

ABSTRACT Despite biomolecule delivery is a natural function of extracellular vesicles (EVs), low loading of exogenous macromolecules such as proteins into EVs limits their interest as convincing protein delivery systems for health applications. In this context, lipid‐anchorage of exogenous cargo int...

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Bibliographic Details
Main Authors: Antonin Marquant, Jade Berthelot, Claudia Bich, Zeineb Ibn Elfekih, Laurianne Simon, Baptiste Robin, Joël Chopineau, David Tianpei Wang, Samuel Jay Emerson, Aijun Wang, Clément Benedetti, Simon Langlois, Laurence Guglielmi, Pierre Martineau, Anne Aubert‐Pouëssel, Marie Morille
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of Extracellular Biology
Subjects:
cell delivery
EV exogenous engineering
exosomes
lipid‐PEG anchorage
process optimisation
protein association
Online Access:https://doi.org/10.1002/jex2.70048
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