Inhibitory Activity of Illicium verum Extracts against Avian Viruses
This study aimed at screening the inhibitory activity of Illicium verum extracts against avian reovirus, infectious bursal disease virus (IBDV), Newcastle disease virus (NDV), and infectious laryngotracheitis virus (ILTV). The cytotoxic and antiviral actions of 3 extracts, absolute methanol (100MOH)...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2020/4594635 |
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| author | Mohammed S. Alhajj Mahmood A. Qasem Saud I. Al-Mufarrej |
| author_facet | Mohammed S. Alhajj Mahmood A. Qasem Saud I. Al-Mufarrej |
| author_sort | Mohammed S. Alhajj |
| collection | DOAJ |
| description | This study aimed at screening the inhibitory activity of Illicium verum extracts against avian reovirus, infectious bursal disease virus (IBDV), Newcastle disease virus (NDV), and infectious laryngotracheitis virus (ILTV). The cytotoxic and antiviral actions of 3 extracts, absolute methanol (100MOH), 50% methanol (50MOH), and aqueous extracts (WA.), were evaluated by MTT assay. The Illicium verum extracts were added to the cultured chick embryo fibroblast (CEF) with tested viruses in three attacks, preinoculation, postinoculation, and simultaneous inoculation. The three extracts showed antiviral inhibitory activity against all tested viruses during simultaneous inoculation and preinoculation except 100MOH and 50MOH that showed no effect against IBDV, thereby suggesting that the extracts have a preventive effect on CEF against viruses. During postinoculation, the extracts exhibited inhibitory effects against NDV and avian reovirus, while no effect against IBDV recorded and only the 100MOH showed an inhibitory effect against ILTV. The initial results of this study suggest that Illicium verum may be a candidate for a natural alternative source for antiviral agents. |
| format | Article |
| id | doaj-art-604875ddedf94a0585feaf0853d327c8 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-604875ddedf94a0585feaf0853d327c82025-02-03T01:26:57ZengWileyAdvances in Virology1687-86391687-86472020-01-01202010.1155/2020/45946354594635Inhibitory Activity of Illicium verum Extracts against Avian VirusesMohammed S. Alhajj0Mahmood A. Qasem1Saud I. Al-Mufarrej2Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Thamar University, Dhamar, YemenDepartment of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi ArabiaDepartment of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi ArabiaThis study aimed at screening the inhibitory activity of Illicium verum extracts against avian reovirus, infectious bursal disease virus (IBDV), Newcastle disease virus (NDV), and infectious laryngotracheitis virus (ILTV). The cytotoxic and antiviral actions of 3 extracts, absolute methanol (100MOH), 50% methanol (50MOH), and aqueous extracts (WA.), were evaluated by MTT assay. The Illicium verum extracts were added to the cultured chick embryo fibroblast (CEF) with tested viruses in three attacks, preinoculation, postinoculation, and simultaneous inoculation. The three extracts showed antiviral inhibitory activity against all tested viruses during simultaneous inoculation and preinoculation except 100MOH and 50MOH that showed no effect against IBDV, thereby suggesting that the extracts have a preventive effect on CEF against viruses. During postinoculation, the extracts exhibited inhibitory effects against NDV and avian reovirus, while no effect against IBDV recorded and only the 100MOH showed an inhibitory effect against ILTV. The initial results of this study suggest that Illicium verum may be a candidate for a natural alternative source for antiviral agents.http://dx.doi.org/10.1155/2020/4594635 |
| spellingShingle | Mohammed S. Alhajj Mahmood A. Qasem Saud I. Al-Mufarrej Inhibitory Activity of Illicium verum Extracts against Avian Viruses Advances in Virology |
| title | Inhibitory Activity of Illicium verum Extracts against Avian Viruses |
| title_full | Inhibitory Activity of Illicium verum Extracts against Avian Viruses |
| title_fullStr | Inhibitory Activity of Illicium verum Extracts against Avian Viruses |
| title_full_unstemmed | Inhibitory Activity of Illicium verum Extracts against Avian Viruses |
| title_short | Inhibitory Activity of Illicium verum Extracts against Avian Viruses |
| title_sort | inhibitory activity of illicium verum extracts against avian viruses |
| url | http://dx.doi.org/10.1155/2020/4594635 |
| work_keys_str_mv | AT mohammedsalhajj inhibitoryactivityofilliciumverumextractsagainstavianviruses AT mahmoodaqasem inhibitoryactivityofilliciumverumextractsagainstavianviruses AT saudialmufarrej inhibitoryactivityofilliciumverumextractsagainstavianviruses |