COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis

COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis

BackgroundRenal cell carcinoma (RCC) progression is closely linked to dysregulation of the ubiquitin-proteasome system, particularly aberrant ubiquitination processes governing protein degradation and cell cycle control. As a pivotal E3 ubiquitin ligase, COP1 mediates substrate-specific ubiquitinati...

Full description

Saved in:
Bibliographic Details
Main Authors: Yuxiao Zheng, Lei Jiang, Feng Qi, Bo Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
COP1
ACSL4
ubiquitination
ferroptosis
RCC
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1570727/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items