Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension
Abstract Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. Although several...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14961 |
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| author | Shanshan Wang Yuanlong Hu Yuqi Wang Yueyue Song Dan Liang Jiufeng Yin Yunlun Li Wenqing Yang Dan Zhang |
| author_facet | Shanshan Wang Yuanlong Hu Yuqi Wang Yueyue Song Dan Liang Jiufeng Yin Yunlun Li Wenqing Yang Dan Zhang |
| author_sort | Shanshan Wang |
| collection | DOAJ |
| description | Abstract Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. Although several single‐omics studies have been conducted on RH, its complex pathogenesis has only been partially elucidated. In this study, metabolomics, proteomics, and transcriptomics were jointly analyzed in healthy subjects and patients with hypertension and RH. The multi‐omics analysis found that differential substances of RH were enriched in the HIF‐1 signaling pathway and that differential substances such as ascorbic acid, reduced glutathione (GSH), choline, citric acid, transferrin receptor (TfR), Egl‐9 family hypoxia‐inducible factor 2 (EGLN2), and glutathione peroxidase 1 (GPX1) were screened out. The results of intergroup comparisons were as follows: RH versus N: ascorbic acid (Fold Change (FC):0.42, p < 0.01), GSH (FC:0.65, p < 0.05), choline (FC:1.32, p < 0.05), citric acid (FC:0.48, p < 0.001), TfR (FC2.32, p < 0.001), GPX1 (FC:16.02, p < 0.001), EGLN2 (FC:0.76, p < 0.001); RH versus EH: ascorbic acid (FC:0.52, p < 0.05), GSH (FC:0.55, p < 0.05), choline (FC:1.28, p < 0.05), citric acid (FC:0.59, p < 0.001), TfR (FC:1.71, p < 0.001), GPX1 (FC:2.11, p < 0.05), EGLN2 (FC:0.76, p < 0.05). These differential substances may reflect the biology of RH. This study provides multi‐omics analysis for a deeper understanding of the complex molecular characteristics of RH, providing new insights into the pathogenesis, early diagnosis, and precise treatment of the disease. |
| format | Article |
| id | doaj-art-603abe323b5a481697d86f026e755ed5 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-603abe323b5a481697d86f026e755ed52025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14961Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant HypertensionShanshan Wang0Yuanlong Hu1Yuqi Wang2Yueyue Song3Dan Liang4Jiufeng Yin5Yunlun Li6Wenqing Yang7Dan Zhang8Innovative Institute of Chinese Medicine and PharmacyShandong University of Traditional Chinese MedicineJinanChinaFirst Faculty of Clinical MedicineShandong University of Traditional Chinese MedicineJinanChinaFirst Faculty of Clinical MedicineShandong University of Traditional Chinese MedicineJinanChinaInnovative Institute of Chinese Medicine and PharmacyShandong University of Traditional Chinese MedicineJinanChinaInnovative Institute of Chinese Medicine and PharmacyShandong University of Traditional Chinese MedicineJinanChinaInnovative Institute of Chinese Medicine and PharmacyShandong University of Traditional Chinese MedicineJinanChinaInnovative Institute of Chinese Medicine and PharmacyShandong University of Traditional Chinese MedicineJinanChinaInnovative Institute of Chinese Medicine and PharmacyShandong University of Traditional Chinese MedicineJinanChinaExperimental CenterShandong University of Traditional Chinese MedicineJinanChinaAbstract Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment. Although several single‐omics studies have been conducted on RH, its complex pathogenesis has only been partially elucidated. In this study, metabolomics, proteomics, and transcriptomics were jointly analyzed in healthy subjects and patients with hypertension and RH. The multi‐omics analysis found that differential substances of RH were enriched in the HIF‐1 signaling pathway and that differential substances such as ascorbic acid, reduced glutathione (GSH), choline, citric acid, transferrin receptor (TfR), Egl‐9 family hypoxia‐inducible factor 2 (EGLN2), and glutathione peroxidase 1 (GPX1) were screened out. The results of intergroup comparisons were as follows: RH versus N: ascorbic acid (Fold Change (FC):0.42, p < 0.01), GSH (FC:0.65, p < 0.05), choline (FC:1.32, p < 0.05), citric acid (FC:0.48, p < 0.001), TfR (FC2.32, p < 0.001), GPX1 (FC:16.02, p < 0.001), EGLN2 (FC:0.76, p < 0.001); RH versus EH: ascorbic acid (FC:0.52, p < 0.05), GSH (FC:0.55, p < 0.05), choline (FC:1.28, p < 0.05), citric acid (FC:0.59, p < 0.001), TfR (FC:1.71, p < 0.001), GPX1 (FC:2.11, p < 0.05), EGLN2 (FC:0.76, p < 0.05). These differential substances may reflect the biology of RH. This study provides multi‐omics analysis for a deeper understanding of the complex molecular characteristics of RH, providing new insights into the pathogenesis, early diagnosis, and precise treatment of the disease.https://doi.org/10.1111/jch.14961biological characteristicsmultiple omicsresistant hypertension |
| spellingShingle | Shanshan Wang Yuanlong Hu Yuqi Wang Yueyue Song Dan Liang Jiufeng Yin Yunlun Li Wenqing Yang Dan Zhang Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension The Journal of Clinical Hypertension biological characteristics multiple omics resistant hypertension |
| title | Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension |
| title_full | Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension |
| title_fullStr | Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension |
| title_full_unstemmed | Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension |
| title_short | Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension |
| title_sort | joint analysis of multiple omics to describe the biological characteristics of resistant hypertension |
| topic | biological characteristics multiple omics resistant hypertension |
| url | https://doi.org/10.1111/jch.14961 |
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