Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice
Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageena...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/808460 |
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| author | Jackson Roberto Guedes da Silva Almeida Grasielly Rocha Souza Juliane Cabral Silva Sarah Raquel Gomes de Lima Saraiva Raimundo Gonçalves de Oliveira Júnior Jullyana de Souza Siqueira Quintans Rosana de Souza Siqueira Barreto Leonardo Rigoldi Bonjardim Sócrates Cabral de Holanda Cavalcanti Lucindo José Quintans Junior |
| author_facet | Jackson Roberto Guedes da Silva Almeida Grasielly Rocha Souza Juliane Cabral Silva Sarah Raquel Gomes de Lima Saraiva Raimundo Gonçalves de Oliveira Júnior Jullyana de Souza Siqueira Quintans Rosana de Souza Siqueira Barreto Leonardo Rigoldi Bonjardim Sócrates Cabral de Holanda Cavalcanti Lucindo José Quintans Junior |
| author_sort | Jackson Roberto Guedes da Silva Almeida |
| collection | DOAJ |
| description | Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant (P<0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P<0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination. |
| format | Article |
| id | doaj-art-6026167a20464c1ca76e5dee70313919 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6026167a20464c1ca76e5dee703139192025-02-03T05:52:15ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/808460808460Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in MiceJackson Roberto Guedes da Silva Almeida0Grasielly Rocha Souza1Juliane Cabral Silva2Sarah Raquel Gomes de Lima Saraiva3Raimundo Gonçalves de Oliveira Júnior4Jullyana de Souza Siqueira Quintans5Rosana de Souza Siqueira Barreto6Leonardo Rigoldi Bonjardim7Sócrates Cabral de Holanda Cavalcanti8Lucindo José Quintans Junior9Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilLaboratório de Farmacologia Pré-Clínica, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilLaboratório de Farmacologia Pré-Clínica, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilLaboratório de Farmacologia Pré-Clínica, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilDepartamento de Farmácia, Universidade Federal de Sergipe,49.000-100 São Cristóvão, SE, BrazilLaboratório de Farmacologia Pré-Clínica, Universidade Federal de Sergipe, 49.000-100 São Cristóvão, SE, BrazilBorneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant (P<0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P<0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.http://dx.doi.org/10.1155/2013/808460 |
| spellingShingle | Jackson Roberto Guedes da Silva Almeida Grasielly Rocha Souza Juliane Cabral Silva Sarah Raquel Gomes de Lima Saraiva Raimundo Gonçalves de Oliveira Júnior Jullyana de Souza Siqueira Quintans Rosana de Souza Siqueira Barreto Leonardo Rigoldi Bonjardim Sócrates Cabral de Holanda Cavalcanti Lucindo José Quintans Junior Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice The Scientific World Journal |
| title | Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice |
| title_full | Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice |
| title_fullStr | Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice |
| title_full_unstemmed | Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice |
| title_short | Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice |
| title_sort | borneol a bicyclic monoterpene alcohol reduces nociceptive behavior and inflammatory response in mice |
| url | http://dx.doi.org/10.1155/2013/808460 |
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