FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma
Abstract Background Clear cell renal cell carcinoma (ccRCC) remains a challenging cancer type due to its resistance to standard treatments. Immunogenic cell death (ICD) has the potential to activate anti-tumor immunity, presenting a promising avenue for ccRCC therapies. Methods We analyzed data from...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01831-w |
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| _version_ | 1832571517904355328 |
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| author | Jian Chen Cheng Zhu Yan He Liping Huang Weizhuo Wang Shuaishuai Huang |
| author_facet | Jian Chen Cheng Zhu Yan He Liping Huang Weizhuo Wang Shuaishuai Huang |
| author_sort | Jian Chen |
| collection | DOAJ |
| description | Abstract Background Clear cell renal cell carcinoma (ccRCC) remains a challenging cancer type due to its resistance to standard treatments. Immunogenic cell death (ICD) has the potential to activate anti-tumor immunity, presenting a promising avenue for ccRCC therapies. Methods We analyzed data from GSE29609, TCGA-KIRC, and GSE159115 to identify ICD-related prognostic genes in ccRCC. By applying consensus clustering, patients were categorized based on ICD modification patterns, and an ICD signature (ICDS) model was developed using a PCA approach. Functional studies were conducted with FOXP3 knockdown in ccRCC cell lines to explore its impact on cell behavior. Results Eleven ICD-related genes were identified as key prognostic indicators in ccRCC, with high ICDS linked to worse survival outcomes. High ICDS also correlated with increased levels of immune-suppressive cells within the tumor microenvironment. FOXP3 was highlighted as a critical gene influencing ICD, where its knockdown significantly reduced ccRCC cell proliferation and migration, underscoring its role in tumor progression. Conclusions This study establishes FOXP3 as a pivotal factor in ICD regulation and ccRCC progression. Targeting FOXP3 and other ICD pathways could enhance treatment efficacy in ccRCC, providing a foundation for ICD-based therapeutic strategies. Evaluating ICD patterns in ccRCC may guide patient-specific interventions, paving the way for improved management of this aggressive cancer. |
| format | Article |
| id | doaj-art-602573510ae5428db006a6c0b230b8b5 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-602573510ae5428db006a6c0b230b8b52025-02-02T12:30:33ZengSpringerDiscover Oncology2730-60112025-01-0116111410.1007/s12672-025-01831-wFOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinomaJian Chen0Cheng Zhu1Yan He2Liping Huang3Weizhuo Wang4Shuaishuai Huang5Medical Department, Ningbo Women and Children’s HospitalMedical Department, Ningbo Women and Children’s HospitalMedical Department, Ningbo Women and Children’s HospitalMedical Department, Ningbo Women and Children’s HospitalCenter for Reproductive Medicine, The Second Affiliated Hospital of Soochow UniversityDepartment of Laboratory, Ningbo Yinzhou No.2 HospitalAbstract Background Clear cell renal cell carcinoma (ccRCC) remains a challenging cancer type due to its resistance to standard treatments. Immunogenic cell death (ICD) has the potential to activate anti-tumor immunity, presenting a promising avenue for ccRCC therapies. Methods We analyzed data from GSE29609, TCGA-KIRC, and GSE159115 to identify ICD-related prognostic genes in ccRCC. By applying consensus clustering, patients were categorized based on ICD modification patterns, and an ICD signature (ICDS) model was developed using a PCA approach. Functional studies were conducted with FOXP3 knockdown in ccRCC cell lines to explore its impact on cell behavior. Results Eleven ICD-related genes were identified as key prognostic indicators in ccRCC, with high ICDS linked to worse survival outcomes. High ICDS also correlated with increased levels of immune-suppressive cells within the tumor microenvironment. FOXP3 was highlighted as a critical gene influencing ICD, where its knockdown significantly reduced ccRCC cell proliferation and migration, underscoring its role in tumor progression. Conclusions This study establishes FOXP3 as a pivotal factor in ICD regulation and ccRCC progression. Targeting FOXP3 and other ICD pathways could enhance treatment efficacy in ccRCC, providing a foundation for ICD-based therapeutic strategies. Evaluating ICD patterns in ccRCC may guide patient-specific interventions, paving the way for improved management of this aggressive cancer.https://doi.org/10.1007/s12672-025-01831-wClear Cell Renal Cell CarcinomaImmunogenic Cell DeathFOXP3PrognosisTumor Immune Microenvironment |
| spellingShingle | Jian Chen Cheng Zhu Yan He Liping Huang Weizhuo Wang Shuaishuai Huang FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma Discover Oncology Clear Cell Renal Cell Carcinoma Immunogenic Cell Death FOXP3 Prognosis Tumor Immune Microenvironment |
| title | FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma |
| title_full | FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma |
| title_fullStr | FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma |
| title_full_unstemmed | FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma |
| title_short | FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma |
| title_sort | foxp3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma |
| topic | Clear Cell Renal Cell Carcinoma Immunogenic Cell Death FOXP3 Prognosis Tumor Immune Microenvironment |
| url | https://doi.org/10.1007/s12672-025-01831-w |
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