A central role for CCR2 in monocyte recruitment and blood–brain barrier disruption during Usutu virus encephalitis

A central role for CCR2 in monocyte recruitment and blood–brain barrier disruption during Usutu virus encephalitis

Abstract Usutu virus (USUV) is an emerging neurotropic flavivirus capable of causing encephalitis in humans. Here, our main goal was to characterize the innate immune response in the brain during USUV encephalitis and to identify strategies to control disease severity. Using an immunocompetent mouse...

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Main Authors: Emily Slowikowski, Céleste Willems, Robertha Mariana Rodrigues Lemes, Sara Schuermans, Nele Berghmans, Rebeca Paiva Fróes Rocha, Erik Martens, Paul Proost, Leen Delang, Rafael Elias Marques, José Carlos Alves Filho, Pedro Elias Marques
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
Usutu virus
Encephalitis
Monocyte
CCR2
Microglia
Blood–brain barrier
Online Access:https://doi.org/10.1186/s12974-025-03435-1
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