MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study
Background. The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case-control study. Methods. A total of 732 community...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/656084 |
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| author | Jiaao Gu Jiesheng Rong Fulin Guan Liying Jiang Shuqing Tao Guofa Guan Tianzun Tao |
| author_facet | Jiaao Gu Jiesheng Rong Fulin Guan Liying Jiang Shuqing Tao Guofa Guan Tianzun Tao |
| author_sort | Jiaao Gu |
| collection | DOAJ |
| description | Background. The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case-control study. Methods. A total of 732 community residents aged 40–84 years participated in the community-based study in Northeast China. After taking physical and radiographic examinations, 420 of the residents were diagnosed OA (216 women and 204 men). The other 312 individuals without any symptoms of osteoarthritis or signs in the radiographs (156 women and 156 men) were considered as healthy controls. After obtaining the DNA of case and control groups, genotypes of the MATN3 SNP6 were determined by polymerase chain reaction followed by restriction enzyme digestion. The numbers of patients with different OA subtypes were also calculated. Results. The distribution of genotypes and alleles of the MATN3 SNP6 between OA patients and controls was different significantly. The BB carrier tends to be associated with the increased osteoarthritis (P = 0.025, OR = 1.724, 95% CI = 1.071–2.77), especially the knee osteoarthritis (P = 0.021, OR = 2.402, 95% CI = 1.141–5.060) and lumber osteoarthritis (P = 0.020, OR = 1.880, 95% CI = 1.103–3.204). Bb carrier increased hand osteoarthritis risk (P = 0.002, OR = 5.380, 95% CI = 1.828–15.835). The B allele might have an effect on the increased knee osteoarthritis (P = 0.000, OR = 3.143, 95% CI = 2.283–4.328). Conclusion. These findings suggest that the MATN3 gene polymorphism might be associated with osteoarthritis in the Chinese Han population. |
| format | Article |
| id | doaj-art-6023c579e3db4a13b6bdf7854adc2f2a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6023c579e3db4a13b6bdf7854adc2f2a2025-02-03T01:31:42ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/656084656084MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control StudyJiaao Gu0Jiesheng Rong1Fulin Guan2Liying Jiang3Shuqing Tao4Guofa Guan5Tianzun Tao6Department of the 2nd Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang, Harbin 150086, ChinaDepartment of the 2nd Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang, Harbin 150086, ChinaDepartment of the 2nd Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang, Harbin 150086, ChinaDepartment of Epidemiology, Public Health College, Harbin Medical University, Heilongjiang, Harbin 150086, ChinaDepartment of the 2nd Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang, Harbin 150086, ChinaThe 1st Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang, Harbin 150086, ChinaDepartment of the 2nd Affiliated Hospital of Harbin Medical University, Harbin Medical University, Heilongjiang, Harbin 150086, ChinaBackground. The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case-control study. Methods. A total of 732 community residents aged 40–84 years participated in the community-based study in Northeast China. After taking physical and radiographic examinations, 420 of the residents were diagnosed OA (216 women and 204 men). The other 312 individuals without any symptoms of osteoarthritis or signs in the radiographs (156 women and 156 men) were considered as healthy controls. After obtaining the DNA of case and control groups, genotypes of the MATN3 SNP6 were determined by polymerase chain reaction followed by restriction enzyme digestion. The numbers of patients with different OA subtypes were also calculated. Results. The distribution of genotypes and alleles of the MATN3 SNP6 between OA patients and controls was different significantly. The BB carrier tends to be associated with the increased osteoarthritis (P = 0.025, OR = 1.724, 95% CI = 1.071–2.77), especially the knee osteoarthritis (P = 0.021, OR = 2.402, 95% CI = 1.141–5.060) and lumber osteoarthritis (P = 0.020, OR = 1.880, 95% CI = 1.103–3.204). Bb carrier increased hand osteoarthritis risk (P = 0.002, OR = 5.380, 95% CI = 1.828–15.835). The B allele might have an effect on the increased knee osteoarthritis (P = 0.000, OR = 3.143, 95% CI = 2.283–4.328). Conclusion. These findings suggest that the MATN3 gene polymorphism might be associated with osteoarthritis in the Chinese Han population.http://dx.doi.org/10.1100/2012/656084 |
| spellingShingle | Jiaao Gu Jiesheng Rong Fulin Guan Liying Jiang Shuqing Tao Guofa Guan Tianzun Tao MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study The Scientific World Journal |
| title | MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study |
| title_full | MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study |
| title_fullStr | MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study |
| title_full_unstemmed | MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study |
| title_short | MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study |
| title_sort | matn3 gene polymorphism is associated with osteoarthritis in chinese han population a community based case control study |
| url | http://dx.doi.org/10.1100/2012/656084 |
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