Association of Social Engagement with Brain Volumes Assessed by Structural MRI
We tested the hypothesis that social engagement is associated with larger brain volumes in a cohort study of 348 older male former lead manufacturing workers (𝑛=305) and population-based controls (𝑛=43), age 48 to 82. Social engagement was measured using a summary scale derived from confirmatory fac...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/512714 |
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| _version_ | 1832555468466159616 |
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| author | Bryan D. James Thomas A. Glass Brian Caffo Jennifer F. Bobb Christos Davatzikos David Yousem Brian S. Schwartz |
| author_facet | Bryan D. James Thomas A. Glass Brian Caffo Jennifer F. Bobb Christos Davatzikos David Yousem Brian S. Schwartz |
| author_sort | Bryan D. James |
| collection | DOAJ |
| description | We tested the hypothesis that social engagement is associated with larger brain volumes in a cohort study of 348 older male former lead manufacturing workers (𝑛=305) and population-based controls (𝑛=43), age 48 to 82. Social engagement was measured using a summary scale derived from confirmatory factor analysis. The volumes of 20 regions of interest (ROIs), including total brain, total gray matter (GM), total white matter (WM), each of the four lobar GM and WM, and 9 smaller structures were derived from T1-weighted structural magnetic resonance images. Linear regression models adjusted for age, education, race/ethnicity, intracranial volume, hypertension, diabetes, and control (versus lead worker) status. Higher social engagement was associated with larger total brain and GM volumes, specifically temporal and occipital GM, but was not associated with WM volumes except for corpus callosum. A voxel-wise analysis supported an association in temporal lobe GM. Using longitudinal data to discern temporal relations, change in ROI volumes over five years showed null associations with current social engagement. Findings are consistent with the hypothesis that social engagement preserves brain tissue, and not consistent with the alternate hypothesis that persons with smaller or shrinking volumes become less socially engaged, though this scenario cannot be ruled out. |
| format | Article |
| id | doaj-art-60215a64d63e467e89ddbfddc9fb3ceb |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-60215a64d63e467e89ddbfddc9fb3ceb2025-02-03T05:48:09ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/512714512714Association of Social Engagement with Brain Volumes Assessed by Structural MRIBryan D. James0Thomas A. Glass1Brian Caffo2Jennifer F. Bobb3Christos Davatzikos4David Yousem5Brian S. Schwartz6Rush Alzheimer’s Disease Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USADepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USADepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USADepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USADepartment of Radiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USAWe tested the hypothesis that social engagement is associated with larger brain volumes in a cohort study of 348 older male former lead manufacturing workers (𝑛=305) and population-based controls (𝑛=43), age 48 to 82. Social engagement was measured using a summary scale derived from confirmatory factor analysis. The volumes of 20 regions of interest (ROIs), including total brain, total gray matter (GM), total white matter (WM), each of the four lobar GM and WM, and 9 smaller structures were derived from T1-weighted structural magnetic resonance images. Linear regression models adjusted for age, education, race/ethnicity, intracranial volume, hypertension, diabetes, and control (versus lead worker) status. Higher social engagement was associated with larger total brain and GM volumes, specifically temporal and occipital GM, but was not associated with WM volumes except for corpus callosum. A voxel-wise analysis supported an association in temporal lobe GM. Using longitudinal data to discern temporal relations, change in ROI volumes over five years showed null associations with current social engagement. Findings are consistent with the hypothesis that social engagement preserves brain tissue, and not consistent with the alternate hypothesis that persons with smaller or shrinking volumes become less socially engaged, though this scenario cannot be ruled out.http://dx.doi.org/10.1155/2012/512714 |
| spellingShingle | Bryan D. James Thomas A. Glass Brian Caffo Jennifer F. Bobb Christos Davatzikos David Yousem Brian S. Schwartz Association of Social Engagement with Brain Volumes Assessed by Structural MRI Journal of Aging Research |
| title | Association of Social Engagement with Brain Volumes Assessed by Structural MRI |
| title_full | Association of Social Engagement with Brain Volumes Assessed by Structural MRI |
| title_fullStr | Association of Social Engagement with Brain Volumes Assessed by Structural MRI |
| title_full_unstemmed | Association of Social Engagement with Brain Volumes Assessed by Structural MRI |
| title_short | Association of Social Engagement with Brain Volumes Assessed by Structural MRI |
| title_sort | association of social engagement with brain volumes assessed by structural mri |
| url | http://dx.doi.org/10.1155/2012/512714 |
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