Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells
Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2019/1914976 |
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| author | Hui Guo Faping Li Heping Qiu Qi Zheng Chao Yang Chao Tang Yuchuan Hou |
| author_facet | Hui Guo Faping Li Heping Qiu Qi Zheng Chao Yang Chao Tang Yuchuan Hou |
| author_sort | Hui Guo |
| collection | DOAJ |
| description | Chitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines. The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT. The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency. Furthermore, cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The present investigation indicated that the positively charged CS-based nanogel could be potentially used as a promising drug delivery system. |
| format | Article |
| id | doaj-art-601c513109844142ac29e82c079e16ed |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-601c513109844142ac29e82c079e16ed2025-02-03T01:12:06ZengWileyInternational Journal of Polymer Science1687-94221687-94302019-01-01201910.1155/2019/19149761914976Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer CellsHui Guo0Faping Li1Heping Qiu2Qi Zheng3Chao Yang4Chao Tang5Yuchuan Hou6Department of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Urinary Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaChitosan (CS), the second most abundant polysaccharide in nature, has been widely developed as a nanoscopic drug delivery vehicle due to its intriguing characteristics. In this work, a positively charged CS-based nanogel was designed and synthesized to inhibit the proliferation of breast cancer cell lines. The model drug of 10-hydroxycamptothecin (HCPT) was entrapped into the core via a facile diffusion to form CS/HCPT. The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency. Furthermore, cell internalization, cytotoxicity, and apoptosis of CS/HCPT were also investigated in vitro. The present investigation indicated that the positively charged CS-based nanogel could be potentially used as a promising drug delivery system.http://dx.doi.org/10.1155/2019/1914976 |
| spellingShingle | Hui Guo Faping Li Heping Qiu Qi Zheng Chao Yang Chao Tang Yuchuan Hou Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells International Journal of Polymer Science |
| title | Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells |
| title_full | Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells |
| title_fullStr | Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells |
| title_full_unstemmed | Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells |
| title_short | Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells |
| title_sort | chitosan based nanogel enhances chemotherapeutic efficacy of 10 hydroxycamptothecin against human breast cancer cells |
| url | http://dx.doi.org/10.1155/2019/1914976 |
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