Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy
Objective. In hypertrophic cardiomyopathy (HCM), myocardial fibrosis is routinely shown by late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) imaging. We evaluated the efficacy of 2 novel contrast-free CMR methods, namely, diffusion-weighted imaging (DWI) and feature-tracking (FT)...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/9931136 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562946374369280 |
|---|---|
| author | Maedeh Sharifian Nahid Rezaeian Sanaz Asadian Ali Mohammadzadeh Ali Nahardani Kianosh Kasani Yaser Toloueitabar Ali Mohammad Farahmand Leila Hosseini |
| author_facet | Maedeh Sharifian Nahid Rezaeian Sanaz Asadian Ali Mohammadzadeh Ali Nahardani Kianosh Kasani Yaser Toloueitabar Ali Mohammad Farahmand Leila Hosseini |
| author_sort | Maedeh Sharifian |
| collection | DOAJ |
| description | Objective. In hypertrophic cardiomyopathy (HCM), myocardial fibrosis is routinely shown by late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) imaging. We evaluated the efficacy of 2 novel contrast-free CMR methods, namely, diffusion-weighted imaging (DWI) and feature-tracking (FT) method, in detecting myocardial fibrosis. Methods. This cross-sectional study was conducted on 26 patients with HCM. Visual and quantitative comparisons were made between DWI and LGE images. Regional longitudinal, circumferential, and radial strains were compared between LGE-positive and LGE-negative segments. Moreover, global strains were compared between LGE-positive and LGE-negative patients as well as between patients with mild and marked LGE. Results. All 3 strains showed significant differences between LGE-positive and LGE-negative segments (P<0.001). The regional longitudinal and circumferential strain parameters showed significant associations with LGE (P<0.001), while regional circumferential strain was the only independent predictor of LGE in logistic regression models (OR: 1.140, 95% CI: 1.073 to 1.207, P<0.001). A comparison of global strains between patients with LGE percentages of below 15% and above 15% demonstrated that global circumferential strain was the only parameter to show impairment in the group with marked myocardial fibrosis, with borderline significance (P=0.09). A review of 212 segments demonstrated a qualitative visual agreement between DWI and LGE in 193 segments (91%). The mean apparent diffusion coefficient was comparable between LGE-positive and LGE-negative segments (P=0.51). Conclusions. FT-CMR, especially regional circumferential strain, can reliably show fibrosis-containing segments in HCM. Further, DWI can function as an efficient qualitative method for the estimation of the fibrosis extent in HCM. |
| format | Article |
| id | doaj-art-601a3f1a3b2d4380bde60440ee97bb3b |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-601a3f1a3b2d4380bde60440ee97bb3b2025-02-03T01:21:26ZengWileyCardiology Research and Practice2090-80162090-05972021-01-01202110.1155/2021/99311369931136Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic CardiomyopathyMaedeh Sharifian0Nahid Rezaeian1Sanaz Asadian2Ali Mohammadzadeh3Ali Nahardani4Kianosh Kasani5Yaser Toloueitabar6Ali Mohammad Farahmand7Leila Hosseini8Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranTehran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranObjective. In hypertrophic cardiomyopathy (HCM), myocardial fibrosis is routinely shown by late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) imaging. We evaluated the efficacy of 2 novel contrast-free CMR methods, namely, diffusion-weighted imaging (DWI) and feature-tracking (FT) method, in detecting myocardial fibrosis. Methods. This cross-sectional study was conducted on 26 patients with HCM. Visual and quantitative comparisons were made between DWI and LGE images. Regional longitudinal, circumferential, and radial strains were compared between LGE-positive and LGE-negative segments. Moreover, global strains were compared between LGE-positive and LGE-negative patients as well as between patients with mild and marked LGE. Results. All 3 strains showed significant differences between LGE-positive and LGE-negative segments (P<0.001). The regional longitudinal and circumferential strain parameters showed significant associations with LGE (P<0.001), while regional circumferential strain was the only independent predictor of LGE in logistic regression models (OR: 1.140, 95% CI: 1.073 to 1.207, P<0.001). A comparison of global strains between patients with LGE percentages of below 15% and above 15% demonstrated that global circumferential strain was the only parameter to show impairment in the group with marked myocardial fibrosis, with borderline significance (P=0.09). A review of 212 segments demonstrated a qualitative visual agreement between DWI and LGE in 193 segments (91%). The mean apparent diffusion coefficient was comparable between LGE-positive and LGE-negative segments (P=0.51). Conclusions. FT-CMR, especially regional circumferential strain, can reliably show fibrosis-containing segments in HCM. Further, DWI can function as an efficient qualitative method for the estimation of the fibrosis extent in HCM.http://dx.doi.org/10.1155/2021/9931136 |
| spellingShingle | Maedeh Sharifian Nahid Rezaeian Sanaz Asadian Ali Mohammadzadeh Ali Nahardani Kianosh Kasani Yaser Toloueitabar Ali Mohammad Farahmand Leila Hosseini Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy Cardiology Research and Practice |
| title | Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy |
| title_full | Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy |
| title_fullStr | Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy |
| title_full_unstemmed | Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy |
| title_short | Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy |
| title_sort | efficacy of novel noncontrast cardiac magnetic resonance methods in indicating fibrosis in hypertrophic cardiomyopathy |
| url | http://dx.doi.org/10.1155/2021/9931136 |
| work_keys_str_mv | AT maedehsharifian efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT nahidrezaeian efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT sanazasadian efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT alimohammadzadeh efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT alinahardani efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT kianoshkasani efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT yasertoloueitabar efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT alimohammadfarahmand efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy AT leilahosseini efficacyofnovelnoncontrastcardiacmagneticresonancemethodsinindicatingfibrosisinhypertrophiccardiomyopathy |