UPR-Mediated Membrane Biogenesis in B Cells
The unfolded protein response (UPR) can coordinate the regulation of gene transcription and protein translation to balance the load of client proteins with the protein folding and degradative capacities of...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/738471 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The unfolded protein
response (UPR) can coordinate the regulation of
gene transcription and protein translation to
balance the load of client proteins with the
protein folding and degradative capacities of
the ER. Increasing evidence also implicates the
UPR in the regulation of lipid synthesis and
membrane biogenesis. The differentiation of
B lymphocytes into antibody-secreting cells is
marked by significant expansion of the ER, the
site for antibody synthesis and assembly. In
activated B cells, the demand for membrane
protein and lipid components leads to activation
of the UPR transcriptional activator XBP1(S)
which, in turn, initiates a cascade of
biochemical events that enhance supplies of
phospholipid precursors and build machinery for
the synthesis, maturation, and transport of
secretory proteins. The alterations in lipid
metabolism that occur during this developmental
transition and the impact of membrane
phospholipid restriction on B cell secretory
characteristics are discussed in this
paper. |
|---|---|
| ISSN: | 2090-2247 2090-2255 |