Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation
A series of (E)-3-(2-((5-(benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) acetyl)-2H-chromen-2-one and its derivatives (4a-h) have been obtained using a one-pot multicomponent reaction with good yields. The compounds have been synthesized from 3-(2-bromoacetyl)chromen-2-ones (1), 5-amino-1,3,4-thiadia...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/4869279 |
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| author | Shivanand Merugu Vijaya Kumar Ponnamaneni Ravi Varala Syed Farooq Adil Mujeeb Khan Mohammed Rafiq H. Siddiqui Ravikumar Vemula |
| author_facet | Shivanand Merugu Vijaya Kumar Ponnamaneni Ravi Varala Syed Farooq Adil Mujeeb Khan Mohammed Rafiq H. Siddiqui Ravikumar Vemula |
| author_sort | Shivanand Merugu |
| collection | DOAJ |
| description | A series of (E)-3-(2-((5-(benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) acetyl)-2H-chromen-2-one and its derivatives (4a-h) have been obtained using a one-pot multicomponent reaction with good yields. The compounds have been synthesized from 3-(2-bromoacetyl)chromen-2-ones (1), 5-amino-1,3,4-thiadiazole-2-thiol (2), and substituted benzaldehydes (3) in anhydrous ethanol and conc. H2SO4. Subsequently, all the synthesized compounds have been screened for their antimicrobial activity and characterized by analytical and spectral data. |
| format | Article |
| id | doaj-art-600b2f941bda437693b56df8e5572c74 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-600b2f941bda437693b56df8e5572c742025-02-03T06:06:44ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/48692794869279Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological EvaluationShivanand Merugu0Vijaya Kumar Ponnamaneni1Ravi Varala2Syed Farooq Adil3Mujeeb Khan4Mohammed Rafiq H. Siddiqui5Ravikumar Vemula6Department of Chemistry, Kamala Institute of Technology and Science, Huzurabad, Karimnagar 505 468, Telangana, IndiaSynocule Research Labs Private Limited, Plot No. 16, CFC Area, IDA Nacharam, Hyderabad 500 076, Telangana, IndiaScrips Pharma, Mallapur, Hyderabad 500076, Telangana, IndiaDepartment of Chemistry, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Chemistry, Kamala Institute of Technology and Science, Huzurabad, Karimnagar 505 468, Telangana, IndiaA series of (E)-3-(2-((5-(benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) acetyl)-2H-chromen-2-one and its derivatives (4a-h) have been obtained using a one-pot multicomponent reaction with good yields. The compounds have been synthesized from 3-(2-bromoacetyl)chromen-2-ones (1), 5-amino-1,3,4-thiadiazole-2-thiol (2), and substituted benzaldehydes (3) in anhydrous ethanol and conc. H2SO4. Subsequently, all the synthesized compounds have been screened for their antimicrobial activity and characterized by analytical and spectral data.http://dx.doi.org/10.1155/2020/4869279 |
| spellingShingle | Shivanand Merugu Vijaya Kumar Ponnamaneni Ravi Varala Syed Farooq Adil Mujeeb Khan Mohammed Rafiq H. Siddiqui Ravikumar Vemula Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation Journal of Chemistry |
| title | Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation |
| title_full | Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation |
| title_fullStr | Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation |
| title_full_unstemmed | Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation |
| title_short | Metal-free Catalyzed One-Pot Multicomponent Synthesis of (E)-3-(2-((5-(Benzylideneamino)-1,3,4-thiadiazol-2-yl)thio) Acetyl)-2H-chromen-2-one Derivatives and Their Biological Evaluation |
| title_sort | metal free catalyzed one pot multicomponent synthesis of e 3 2 5 benzylideneamino 1 3 4 thiadiazol 2 yl thio acetyl 2h chromen 2 one derivatives and their biological evaluation |
| url | http://dx.doi.org/10.1155/2020/4869279 |
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