The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets
T cells are an important part of the adaptive immune system and play critical roles in the elimination of various pathogens. T cells could differentiate into distinct cellular subsets under different extracellular signals and then play different roles in maintaining host homeostasis and defense. The...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3406032 |
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| author | Peng Wang Qian Zhang Liang Tan Yanan Xu Xubiao Xie Yong Zhao |
| author_facet | Peng Wang Qian Zhang Liang Tan Yanan Xu Xubiao Xie Yong Zhao |
| author_sort | Peng Wang |
| collection | DOAJ |
| description | T cells are an important part of the adaptive immune system and play critical roles in the elimination of various pathogens. T cells could differentiate into distinct cellular subsets under different extracellular signals and then play different roles in maintaining host homeostasis and defense. The mechanistic target of rapamycin (mTOR) is a conserved intracellular serine/threonine kinase which belongs to the phosphoinositide 3-kinase- (PI3K-) related kinase family. The mTOR signaling pathway is closely involved in a variety of cell biological processes, including cell growth and cell metabolism, by senses and integrates various environmental cues. Recent studies showed that mTOR including mTORC1 and mTORC2 is closely involved in the development of T cell subpopulations such as Th1, Th2, Th9, Th17, follicular helper T cells (Tfh), and Treg cells through distinctive pathways. We herein mainly focused on the recent progress in understanding the roles of mTOR in regulating the development and differentiation of CD4+ T cell subsets. |
| format | Article |
| id | doaj-art-5fedd328b5cc4509b3190b44abdc8db6 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5fedd328b5cc4509b3190b44abdc8db62025-02-03T06:05:13ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/34060323406032The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell SubsetsPeng Wang0Qian Zhang1Liang Tan2Yanan Xu3Xubiao Xie4Yong Zhao5State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Urological Organ Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Urological Organ Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Beijing, ChinaT cells are an important part of the adaptive immune system and play critical roles in the elimination of various pathogens. T cells could differentiate into distinct cellular subsets under different extracellular signals and then play different roles in maintaining host homeostasis and defense. The mechanistic target of rapamycin (mTOR) is a conserved intracellular serine/threonine kinase which belongs to the phosphoinositide 3-kinase- (PI3K-) related kinase family. The mTOR signaling pathway is closely involved in a variety of cell biological processes, including cell growth and cell metabolism, by senses and integrates various environmental cues. Recent studies showed that mTOR including mTORC1 and mTORC2 is closely involved in the development of T cell subpopulations such as Th1, Th2, Th9, Th17, follicular helper T cells (Tfh), and Treg cells through distinctive pathways. We herein mainly focused on the recent progress in understanding the roles of mTOR in regulating the development and differentiation of CD4+ T cell subsets.http://dx.doi.org/10.1155/2020/3406032 |
| spellingShingle | Peng Wang Qian Zhang Liang Tan Yanan Xu Xubiao Xie Yong Zhao The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets Journal of Immunology Research |
| title | The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets |
| title_full | The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets |
| title_fullStr | The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets |
| title_full_unstemmed | The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets |
| title_short | The Regulatory Effects of mTOR Complexes in the Differentiation and Function of CD4+ T Cell Subsets |
| title_sort | regulatory effects of mtor complexes in the differentiation and function of cd4 t cell subsets |
| url | http://dx.doi.org/10.1155/2020/3406032 |
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