Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo
Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress m...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2015-03-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2015-0007 |
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| author | Bártíková Hana Skálová Lenka Valentová Kateřina Matoušková Petra Szotáková Barbora Martin Jan Kvita Vojtěch Boušová Iva |
| author_facet | Bártíková Hana Skálová Lenka Valentová Kateřina Matoušková Petra Szotáková Barbora Martin Jan Kvita Vojtěch Boušová Iva |
| author_sort | Bártíková Hana |
| collection | DOAJ |
| description | Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase |
| format | Article |
| id | doaj-art-5feb09c725eb4893b9d3c75fbfb3d1f3 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-5feb09c725eb4893b9d3c75fbfb3d1f32025-02-02T08:32:25ZengSciendoActa Pharmaceutica1846-95582015-03-01651657310.1515/acph-2015-0007acph-2015-0007Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivoBártíková Hana0Skálová Lenka1Valentová Kateřina2Matoušková Petra3Szotáková Barbora4Martin Jan5Kvita Vojtěch6Boušová Iva7Faculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech RepublicFaculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech RepublicFaculty of Medicine and Dentistry Palacký University CZ-775 15 Olomouc Czech RepublicFaculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech RepublicFaculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech RepublicFaculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech RepublicFaculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech RepublicFaculty of Pharmacy Charles University in Prague CZ-500 05 Hradec Králové Czech RepublicGreen tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutasehttps://doi.org/10.1515/acph-2015-0007green tea extractdietary supplementflavonoidsgreen tea catechinsantioxidant enzymes |
| spellingShingle | Bártíková Hana Skálová Lenka Valentová Kateřina Matoušková Petra Szotáková Barbora Martin Jan Kvita Vojtěch Boušová Iva Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo Acta Pharmaceutica green tea extract dietary supplement flavonoids green tea catechins antioxidant enzymes |
| title | Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo |
| title_full | Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo |
| title_fullStr | Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo |
| title_full_unstemmed | Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo |
| title_short | Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo |
| title_sort | effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo |
| topic | green tea extract dietary supplement flavonoids green tea catechins antioxidant enzymes |
| url | https://doi.org/10.1515/acph-2015-0007 |
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