Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases
Conventional cancer drugs are small molecules that target specific pathways. We introduced PCMS, a 26 kDa supramolecule combining sensors (S), molecular motors (M), and switching molecules (C), integrated within a fourth-generation PAMAM structure (P). PCMS identifies and deactivates cancer cell nuc...
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MDPI AG
2024-12-01
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| Series: | Fractal and Fractional |
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| Online Access: | https://www.mdpi.com/2504-3110/9/1/8 |
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| author | Parama Dey Anup Singhania Ajaikumar B. Kunnumakkara Subrata Ghosh Anirban Bandyopadhyay |
| author_facet | Parama Dey Anup Singhania Ajaikumar B. Kunnumakkara Subrata Ghosh Anirban Bandyopadhyay |
| author_sort | Parama Dey |
| collection | DOAJ |
| description | Conventional cancer drugs are small molecules that target specific pathways. We introduced PCMS, a 26 kDa supramolecule combining sensors (S), molecular motors (M), and switching molecules (C), integrated within a fourth-generation PAMAM structure (P). PCMS identifies and deactivates cancer cell nucleus dynamics. A decade ago, we demonstrated programmable, clock-like interactions among the S-C-M components. In this study, we captured images of fractal patterns formed by chromosomal compartments and developed a theoretical model of their fractal dynamics. We showed that the nucleus behaves like a cavity, producing resonance effects similar to Chladni patterns. When the external agent, PCMS, interacts with this cavity, it generates a fractal pattern. We identified and mapped five key phase transitions that ultimately lead to the breakdown of cancer cell nuclei. |
| format | Article |
| id | doaj-art-5fd6e6c33ad94b6ea6a25559061dbfce |
| institution | Kabale University |
| issn | 2504-3110 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fractal and Fractional |
| spelling | doaj-art-5fd6e6c33ad94b6ea6a25559061dbfce2025-01-24T13:33:21ZengMDPI AGFractal and Fractional2504-31102024-12-0191810.3390/fractalfract9010008Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration PhasesParama Dey0Anup Singhania1Ajaikumar B. Kunnumakkara2Subrata Ghosh3Anirban Bandyopadhyay4Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, IndiaChemical Sciences and Technology Division, CSIR-North East Institute of Science and Technology (NEIST), Jorhat 785006, Assam, IndiaCancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, IndiaChemical Sciences and Technology Division, CSIR-North East Institute of Science and Technology (NEIST), Jorhat 785006, Assam, IndiaInternational Center for Materials and Nanoarchitectronics (MANA), Research Center for Advanced Measurement and Characterization (RCAMC), National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 3050047, Ibaraki, JapanConventional cancer drugs are small molecules that target specific pathways. We introduced PCMS, a 26 kDa supramolecule combining sensors (S), molecular motors (M), and switching molecules (C), integrated within a fourth-generation PAMAM structure (P). PCMS identifies and deactivates cancer cell nucleus dynamics. A decade ago, we demonstrated programmable, clock-like interactions among the S-C-M components. In this study, we captured images of fractal patterns formed by chromosomal compartments and developed a theoretical model of their fractal dynamics. We showed that the nucleus behaves like a cavity, producing resonance effects similar to Chladni patterns. When the external agent, PCMS, interacts with this cavity, it generates a fractal pattern. We identified and mapped five key phase transitions that ultimately lead to the breakdown of cancer cell nuclei.https://www.mdpi.com/2504-3110/9/1/8PCMS nanobotchladni patternfractal patternlung cancer |
| spellingShingle | Parama Dey Anup Singhania Ajaikumar B. Kunnumakkara Subrata Ghosh Anirban Bandyopadhyay Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases Fractal and Fractional PCMS nanobot chladni pattern fractal pattern lung cancer |
| title | Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases |
| title_full | Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases |
| title_fullStr | Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases |
| title_full_unstemmed | Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases |
| title_short | Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases |
| title_sort | chladni and fractal dynamics dual mode marker to map cancer cell nucleus disintegration phases |
| topic | PCMS nanobot chladni pattern fractal pattern lung cancer |
| url | https://www.mdpi.com/2504-3110/9/1/8 |
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