Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia
The mesolimbic dopamine (DA) system has been associated with the pathogenesis of schizophrenia. Here, we examined DA-containing neuronal structures of the ventral tegmental area (VTA) of an autopsy case of disorganized type of schizophrenia (75-year-old female), using tyrosine hydroxylase (TH) immun...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/381059 |
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| author | Keiko Ikemoto Tatsuro Oda Akiyoshi Nishimura Katsuji Nishi |
| author_facet | Keiko Ikemoto Tatsuro Oda Akiyoshi Nishimura Katsuji Nishi |
| author_sort | Keiko Ikemoto |
| collection | DOAJ |
| description | The mesolimbic dopamine (DA) system has been associated with the pathogenesis of schizophrenia. Here, we examined DA-containing neuronal structures of the ventral tegmental area (VTA) of an autopsy case of disorganized type of schizophrenia (75-year-old female), using tyrosine hydroxylase (TH) immunohistochemistry. A free floating method using 50-μm cryostat sections and three-dimensional imaging analyzer AxioVision were applied to observe the wide range structures of TH-immunoreactive (-ir) neurons. TH-ir neuronal cell bodies in the VTA of the present case had irregular shape and various size, and TH-ir neuronal processes had irregular thickness and straightened shape or curved shape having many corners, when compared to a control autopsy case with no detectable neurological and psychiatric diseases (64-year-old male). The mechanisms underlying the morphological characteristics of DA neurons of the brains with schizophrenia should be elucidated epigenetically as well as genetically. |
| format | Article |
| id | doaj-art-5fc755502b964a39b0fc8d6129eb160d |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-5fc755502b964a39b0fc8d6129eb160d2025-02-03T06:42:18ZengWileyCase Reports in Neurological Medicine2090-66682090-66762011-01-01201110.1155/2011/381059381059Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of SchizophreniaKeiko Ikemoto0Tatsuro Oda1Akiyoshi Nishimura2Katsuji Nishi3Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, JapanDepartment of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba 266-0007, JapanDepartment of Forensic Medicine, Institute of Health Bioscience , Tokushima University Graduate School, Tokushima 770-8503, JapanDepartment of Legal Medicine, Shiga University of Medical Science, Otsu 520-2192, JapanThe mesolimbic dopamine (DA) system has been associated with the pathogenesis of schizophrenia. Here, we examined DA-containing neuronal structures of the ventral tegmental area (VTA) of an autopsy case of disorganized type of schizophrenia (75-year-old female), using tyrosine hydroxylase (TH) immunohistochemistry. A free floating method using 50-μm cryostat sections and three-dimensional imaging analyzer AxioVision were applied to observe the wide range structures of TH-immunoreactive (-ir) neurons. TH-ir neuronal cell bodies in the VTA of the present case had irregular shape and various size, and TH-ir neuronal processes had irregular thickness and straightened shape or curved shape having many corners, when compared to a control autopsy case with no detectable neurological and psychiatric diseases (64-year-old male). The mechanisms underlying the morphological characteristics of DA neurons of the brains with schizophrenia should be elucidated epigenetically as well as genetically.http://dx.doi.org/10.1155/2011/381059 |
| spellingShingle | Keiko Ikemoto Tatsuro Oda Akiyoshi Nishimura Katsuji Nishi Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia Case Reports in Neurological Medicine |
| title | Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia |
| title_full | Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia |
| title_fullStr | Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia |
| title_full_unstemmed | Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia |
| title_short | Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia |
| title_sort | dopamine neurons in the ventral tegmental area an autopsy case of disorganized type of schizophrenia |
| url | http://dx.doi.org/10.1155/2011/381059 |
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