Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degeneration
Purpose. Analysis of optical coherence tomography (OCT) biomarkers for anatomical results prediction of anti-angiogenic therapy (anti-VEGF) of pigment epithelial detachments (PED) in neovascular macular degeneration (n-AMD). Material and methods. Primary tomograms of 260 patients with PED higher tha...
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| Format: | Article |
| Language: | Russian |
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Publishing house "Ophthalmology"
2024-06-01
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| Series: | Офтальмохирургия |
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| Online Access: | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/632/903 |
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| author | E.V. Kozina S.N. Sakhnov V.V. Myasnikova E.V. Bykova |
| author_facet | E.V. Kozina S.N. Sakhnov V.V. Myasnikova E.V. Bykova |
| author_sort | E.V. Kozina |
| collection | DOAJ |
| description | Purpose. Analysis of optical coherence tomography (OCT) biomarkers for anatomical results prediction of anti-angiogenic therapy (anti-VEGF) of pigment epithelial detachments (PED) in neovascular macular degeneration (n-AMD). Material and methods. Primary tomograms of 260 patients with PED higher than 200 μm were analyzed. The shape, height, length of the detachment and subpigmentary space reflectivity were assessed. After anti-VEGF injections, reattachment of PED according to OCT was observed in 114cases (44%) – 1st group; in 111 cases (43%) OCT showed PED resistance – 2nd group; in 35 cases (13%), the pigment epithelium tear (RPET) of 3–4 degrees was happened – 3rd group. In each OCT were studied of the following biomarkers: the ellipsoidal zone and RPE integrity, intra – and subretinal fluid, the drusen under RPE around PED, hyperreflective foci in retina. Results. A statistically significant difference was revealed between 1st and 2nd groups in the height and length of pigment epithelium detachment: PED height (506.2±204.3 μm) and length (3206.2±722.1 μm) have a tendency to reattachment during anti-VEGF therapy (р<0.05). High PED with neuroepithelial detachment has a higher risk of RPET (р<0.05). Presence of RPE defects and large hyperreflective foci in the retina can be considered as a predictor of the PED reattachment (р<0.05). Low PED with reflectivity subpigmentary space is a predictor of PED resistance (р<0.05). Conclusion. Patients with high PED, with neuroepithelial detachment, should be given anti-VEGF therapy with great caution. Lower PED with hyperreflectity under PED tend to be anatomically resistant to therapy. Biomarkers of the adherence of the PE can be RPE defects and large hyperreflective inclusions in the internal layers. |
| format | Article |
| id | doaj-art-5fc613fc00a340f6a86dc27b4d24fcea |
| institution | OA Journals |
| issn | 0235-4160 2312-4970 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | Publishing house "Ophthalmology" |
| record_format | Article |
| series | Офтальмохирургия |
| spelling | doaj-art-5fc613fc00a340f6a86dc27b4d24fcea2025-08-20T02:16:03ZrusPublishing house "Ophthalmology"Офтальмохирургия0235-41602312-49702024-06-011392738010.25276/0235-4160-2024-2-73-80Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degenerationE.V. Kozina0https://orcid.org/0000-0002-2959-9649S.N. Sakhnov1https://orcid.org/0000-0003-2100-2972V.V. Myasnikova2https://orcid.org/0000-0003-1748-7962E.V. Bykova3https://orcid.org/0000-0001-9187-4202S. Fyodorov Eye Microsurgery Federal State Institution, Krasnodar branch, Krasnodar, Russian FederationS. Fyodorov Eye Microsurgery Federal State Institution, Krasnodar branch, Krasnodar, Russian Federation; Kuban State Medical University Ministry of Health of Russia, Krasnodar, Russian Federation Kuban State Medical University Ministry of Health of Russia, Krasnodar, Russian FederationS. Fyodorov Eye Microsurgery Federal State Institution, Krasnodar branch, Krasnodar, Russian FederationPurpose. Analysis of optical coherence tomography (OCT) biomarkers for anatomical results prediction of anti-angiogenic therapy (anti-VEGF) of pigment epithelial detachments (PED) in neovascular macular degeneration (n-AMD). Material and methods. Primary tomograms of 260 patients with PED higher than 200 μm were analyzed. The shape, height, length of the detachment and subpigmentary space reflectivity were assessed. After anti-VEGF injections, reattachment of PED according to OCT was observed in 114cases (44%) – 1st group; in 111 cases (43%) OCT showed PED resistance – 2nd group; in 35 cases (13%), the pigment epithelium tear (RPET) of 3–4 degrees was happened – 3rd group. In each OCT were studied of the following biomarkers: the ellipsoidal zone and RPE integrity, intra – and subretinal fluid, the drusen under RPE around PED, hyperreflective foci in retina. Results. A statistically significant difference was revealed between 1st and 2nd groups in the height and length of pigment epithelium detachment: PED height (506.2±204.3 μm) and length (3206.2±722.1 μm) have a tendency to reattachment during anti-VEGF therapy (р<0.05). High PED with neuroepithelial detachment has a higher risk of RPET (р<0.05). Presence of RPE defects and large hyperreflective foci in the retina can be considered as a predictor of the PED reattachment (р<0.05). Low PED with reflectivity subpigmentary space is a predictor of PED resistance (р<0.05). Conclusion. Patients with high PED, with neuroepithelial detachment, should be given anti-VEGF therapy with great caution. Lower PED with hyperreflectity under PED tend to be anatomically resistant to therapy. Biomarkers of the adherence of the PE can be RPE defects and large hyperreflective inclusions in the internal layers.https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/632/903retinal pigment epithelium detachmentpigment epithelium tearoct biomarkershyperreflective fociantiangiogenic therapy |
| spellingShingle | E.V. Kozina S.N. Sakhnov V.V. Myasnikova E.V. Bykova Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degeneration Офтальмохирургия retinal pigment epithelium detachment pigment epithelium tear oct biomarkers hyperreflective foci antiangiogenic therapy |
| title | Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degeneration |
| title_full | Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degeneration |
| title_fullStr | Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degeneration |
| title_full_unstemmed | Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degeneration |
| title_short | Analysis of OCT predictors of anatomical and functional results of anti-VEGF therapy of pigment epithelium detachment in neovascular age-related macular degeneration |
| title_sort | analysis of oct predictors of anatomical and functional results of anti vegf therapy of pigment epithelium detachment in neovascular age related macular degeneration |
| topic | retinal pigment epithelium detachment pigment epithelium tear oct biomarkers hyperreflective foci antiangiogenic therapy |
| url | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/632/903 |
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