Research on the mechanism of Astragaloside Ⅳ in regulating urotensin Ⅱ-induced renal tubular epithelial cells injury through the RhoA/ROCK1 signaling pathway

Research on the mechanism of Astragaloside Ⅳ in regulating urotensin Ⅱ-induced renal tubular epithelial cells injury through the RhoA/ROCK1 signaling pathway

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ObjectiveTo explore the mechanism by which astragaloside IV （AS-IV） regulates the injury of normal rat kidney cells-52E （NRK-52E） induced by Urotensin II （UII） through the Ras homolog gene family member A （RhoA）/Rho-associated protein kinase 1 （ROCK1） signaling pathway.MethodsNRK-52E cells were cult...

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Bibliographic Details
Main Authors: Liu Qian-wei, Liu Wen-yuan, Fang Jing-ai
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Nephrology 2025-03-01
Series:Linchuang shenzangbing zazhi
Subjects:
injury
urotensin ⅱ
astragaloside ⅳ
ras homolog gene family member a/rho-associated protein kinase 1
Online Access:http://www.lcszb.com/article/doi/10.3969/j.issn.1671-2390.2025.03.008
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