Neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy in gastric cancer and gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis of single-arm studies

Neoadjuvant PD-1/PD-L1 inhibitors combined with chemotherapy in gastric cancer and gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis of single-arm studies

BackgroundNeoadjuvant chemotherapy, particularly neoadjuvant immunotherapy, has achieved significant progress in treating gastric cancer (GC) and gastroesophageal junction (GEJ) adenocarcinoma. While PD-1/PD-L1 inhibitors have improved survival outcomes in some patients, the efficacy of combining ne...

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Bibliographic Details
Main Authors: Jun Leng, Min Liu, Qianwen Wang, Huaiwu Jiang, Jin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Medicine
Subjects:
combination therapy
efficacy
meta-analysis
neoadjuvant immunotherapy
gastric cancer/gastroesophageal junction tumors
safety
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1625259/full
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