Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria
Previous studies indicate that 25–45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/267278 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564536351129600 |
|---|---|
| author | Aysegul Alpay Nilgün Solak Tekin Ishak Özel Tekin H. Cevdet Altinyazar Rafet Koca Saniye Çınar |
| author_facet | Aysegul Alpay Nilgün Solak Tekin Ishak Özel Tekin H. Cevdet Altinyazar Rafet Koca Saniye Çınar |
| author_sort | Aysegul Alpay |
| collection | DOAJ |
| description | Previous studies indicate that 25–45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62%) patients and 5 (10%) control patients had positive ASST; 21 (42%) patients and 3 (6%) control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASST P<0.001; APST P<0.001). Thirteen (26%) patients and 5 (10%) control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TG P=0.317; anti-TPO P=0.269). We consider that the ASST and APST can both be used as in vivo tests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU. |
| format | Article |
| id | doaj-art-5fb5023c678b43bd8bc0566598072a60 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-5fb5023c678b43bd8bc0566598072a602025-02-03T01:10:48ZengWileyDermatology Research and Practice1687-61051687-61132013-01-01201310.1155/2013/267278267278Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous UrticariaAysegul Alpay0Nilgün Solak Tekin1Ishak Özel Tekin2H. Cevdet Altinyazar3Rafet Koca4Saniye Çınar5Bulent Ecevit University, School of Medicine, Department of Dermatology, Kozlu, 67600 Zonguldak, TurkeyBulent Ecevit University, School of Medicine, Department of Dermatology, Kozlu, 67600 Zonguldak, TurkeyBulent Ecevit University, School of Medicine, Department of Immunology, TurkeySelcuk University, Selcuklu Medical Faculty, Department of Dermatology, TurkeyBulent Ecevit University, School of Medicine, Department of Dermatology, Kozlu, 67600 Zonguldak, TurkeyBulent Ecevit University, School of Medicine, Department of Dermatology, Kozlu, 67600 Zonguldak, TurkeyPrevious studies indicate that 25–45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62%) patients and 5 (10%) control patients had positive ASST; 21 (42%) patients and 3 (6%) control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASST P<0.001; APST P<0.001). Thirteen (26%) patients and 5 (10%) control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TG P=0.317; anti-TPO P=0.269). We consider that the ASST and APST can both be used as in vivo tests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU.http://dx.doi.org/10.1155/2013/267278 |
| spellingShingle | Aysegul Alpay Nilgün Solak Tekin Ishak Özel Tekin H. Cevdet Altinyazar Rafet Koca Saniye Çınar Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria Dermatology Research and Practice |
| title | Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria |
| title_full | Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria |
| title_fullStr | Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria |
| title_full_unstemmed | Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria |
| title_short | Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria |
| title_sort | autologous serum skin test versus autologous plasma skin test in patients with chronic spontaneous urticaria |
| url | http://dx.doi.org/10.1155/2013/267278 |
| work_keys_str_mv | AT aysegulalpay autologousserumskintestversusautologousplasmaskintestinpatientswithchronicspontaneousurticaria AT nilgunsolaktekin autologousserumskintestversusautologousplasmaskintestinpatientswithchronicspontaneousurticaria AT ishakozeltekin autologousserumskintestversusautologousplasmaskintestinpatientswithchronicspontaneousurticaria AT hcevdetaltinyazar autologousserumskintestversusautologousplasmaskintestinpatientswithchronicspontaneousurticaria AT rafetkoca autologousserumskintestversusautologousplasmaskintestinpatientswithchronicspontaneousurticaria AT saniyecınar autologousserumskintestversusautologousplasmaskintestinpatientswithchronicspontaneousurticaria |