Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells
Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions. This highly viscous polysaccharide is not only a lubricator, but also a significant regulator of cellular behaviors during embryogenesis, morphogenes...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/346972 |
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| author | Mairim Alexandra Solis Ying-Hui Chen Tzyy Yue Wong Vanessa Zaiatz Bittencourt Yen-Cheng Lin Lynn L. H. Huang |
| author_facet | Mairim Alexandra Solis Ying-Hui Chen Tzyy Yue Wong Vanessa Zaiatz Bittencourt Yen-Cheng Lin Lynn L. H. Huang |
| author_sort | Mairim Alexandra Solis |
| collection | DOAJ |
| description | Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions. This highly viscous polysaccharide is not only a lubricator, but also a significant regulator of cellular behaviors during embryogenesis, morphogenesis, migration, proliferation, and drug resistance in many cell types, including stem cells. Most hyaluronan functions require binding to its cellular receptors CD44, LYVE-1, HARE, layilin, and RHAMM. After binding, proteins are recruited and messages are sent to alter cellular activities. When low concentrations of hyaluronan are applied to stem cells, the proliferative activity is enhanced. However, at high concentrations, stem cells acquire a dormant state and induce a multidrug resistance phenotype. Due to the influence of hyaluronan on cells and tissue morphogenesis, with regards to cardiogenesis, chondrogenesis, osteogenesis, and neurogenesis, it is now been utilized as a biomaterial for tissue regeneration. This paper summarizes the most important and recent findings regarding the regulation of hyaluronan in cells. |
| format | Article |
| id | doaj-art-5fad437217894032870ae0de16a7ecab |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-5fad437217894032870ae0de16a7ecab2025-02-03T00:59:51ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/346972346972Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem CellsMairim Alexandra Solis0Ying-Hui Chen1Tzyy Yue Wong2Vanessa Zaiatz Bittencourt3Yen-Cheng Lin4Lynn L. H. Huang5Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, TaiwanInstitute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, TaiwanInstitute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, TaiwanInstitute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, TaiwanInstitute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, TaiwanInstitute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, TaiwanHyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions. This highly viscous polysaccharide is not only a lubricator, but also a significant regulator of cellular behaviors during embryogenesis, morphogenesis, migration, proliferation, and drug resistance in many cell types, including stem cells. Most hyaluronan functions require binding to its cellular receptors CD44, LYVE-1, HARE, layilin, and RHAMM. After binding, proteins are recruited and messages are sent to alter cellular activities. When low concentrations of hyaluronan are applied to stem cells, the proliferative activity is enhanced. However, at high concentrations, stem cells acquire a dormant state and induce a multidrug resistance phenotype. Due to the influence of hyaluronan on cells and tissue morphogenesis, with regards to cardiogenesis, chondrogenesis, osteogenesis, and neurogenesis, it is now been utilized as a biomaterial for tissue regeneration. This paper summarizes the most important and recent findings regarding the regulation of hyaluronan in cells.http://dx.doi.org/10.1155/2012/346972 |
| spellingShingle | Mairim Alexandra Solis Ying-Hui Chen Tzyy Yue Wong Vanessa Zaiatz Bittencourt Yen-Cheng Lin Lynn L. H. Huang Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells Biochemistry Research International |
| title | Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells |
| title_full | Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells |
| title_fullStr | Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells |
| title_full_unstemmed | Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells |
| title_short | Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells |
| title_sort | hyaluronan regulates cell behavior a potential niche matrix for stem cells |
| url | http://dx.doi.org/10.1155/2012/346972 |
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