The <i>MCPH7</i> Gene Product STIL Is Essential for Dendritic Spine Formation

The <i>MCPH7</i> Gene Product STIL Is Essential for Dendritic Spine Formation

Dendritic spine formation/maintenance is highly dependent on actin cytoskeletal dynamics, which is regulated by small GTPases Rac1 and Cdc42 through their downstream p21-activated kinase/LIM-kinase-I/cofilin pathway. ARHGEF7, also known as ß-PIX, is a guanine nucleotide exchange factor for Rac1 and...

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Bibliographic Details
Main Authors: Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
MCPH7
STIL
dendritic spine
ARHGEF7
Rac1
Cdc42
Online Access:https://www.mdpi.com/2073-4409/14/2/62
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