Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes
The proinsulin-to-C-peptide (PI:C) ratio is an index applied during the early stage of pancreatic β-cell dysfunction. The aim of this study was to identify the characteristics associated with the PI:C ratio to discuss pancreatic β-cell dysfunction progression during the natural course of type 2 diab...
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| Format: | Article |
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The Japan Endocrine Society
2024-04-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/4/71_EJ23-0525/_html/-char/en |
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| author | Aika Miya Akinobu Nakamura Hiroshi Nomoto Hiraku Kameda Tatsuya Atsumi |
| author_facet | Aika Miya Akinobu Nakamura Hiroshi Nomoto Hiraku Kameda Tatsuya Atsumi |
| author_sort | Aika Miya |
| collection | DOAJ |
| description | The proinsulin-to-C-peptide (PI:C) ratio is an index applied during the early stage of pancreatic β-cell dysfunction. The aim of this study was to identify the characteristics associated with the PI:C ratio to discuss pancreatic β-cell dysfunction progression during the natural course of type 2 diabetes and its relationship with glycemic management. This multicenter, prospective observational study included 272 outpatients with type 2 diabetes. Continuous glucose monitoring was performed and fasting blood samples were collected and analyzed. We identified the clinical factors associated with the PI:C ratio by multiple regression analysis. The mean age of the cohort was 68.0 years, mean hemoglobin A1c 7.1% (54 mmol/mol), and mean body mass index 24.9 kg/m2. Multiple regression analysis showed that a prolonged time above the target glucose range (>180 mg/dL) and high body mass index contributed to a high PI:C ratio. However, no associations were found between the PI:C ratio and glucose variability indices. These findings suggested that the PI:C ratio is positively associated with a prolonged hyperglycemic time in type 2 diabetes, whereas its relationship with glucose variability remains unclear. |
| format | Article |
| id | doaj-art-5fa4abb554d5466ab650ee1e4a4f32f9 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-5fa4abb554d5466ab650ee1e4a4f32f92025-01-22T06:37:03ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-04-0171440340810.1507/endocrj.EJ23-0525endocrjPositive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetesAika Miya0Akinobu Nakamura1Hiroshi Nomoto2Hiraku Kameda3Tatsuya Atsumi4Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, JapanThe proinsulin-to-C-peptide (PI:C) ratio is an index applied during the early stage of pancreatic β-cell dysfunction. The aim of this study was to identify the characteristics associated with the PI:C ratio to discuss pancreatic β-cell dysfunction progression during the natural course of type 2 diabetes and its relationship with glycemic management. This multicenter, prospective observational study included 272 outpatients with type 2 diabetes. Continuous glucose monitoring was performed and fasting blood samples were collected and analyzed. We identified the clinical factors associated with the PI:C ratio by multiple regression analysis. The mean age of the cohort was 68.0 years, mean hemoglobin A1c 7.1% (54 mmol/mol), and mean body mass index 24.9 kg/m2. Multiple regression analysis showed that a prolonged time above the target glucose range (>180 mg/dL) and high body mass index contributed to a high PI:C ratio. However, no associations were found between the PI:C ratio and glucose variability indices. These findings suggested that the PI:C ratio is positively associated with a prolonged hyperglycemic time in type 2 diabetes, whereas its relationship with glucose variability remains unclear.https://www.jstage.jst.go.jp/article/endocrj/71/4/71_EJ23-0525/_html/-char/enproinsulintype 2 diabetescontinuous glucose monitoringβ-cell dysfunction |
| spellingShingle | Aika Miya Akinobu Nakamura Hiroshi Nomoto Hiraku Kameda Tatsuya Atsumi Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes Endocrine Journal proinsulin type 2 diabetes continuous glucose monitoring β-cell dysfunction |
| title | Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes |
| title_full | Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes |
| title_fullStr | Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes |
| title_full_unstemmed | Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes |
| title_short | Positive association between the proinsulin-to-C-peptide ratio and prolonged hyperglycemic time in type 2 diabetes |
| title_sort | positive association between the proinsulin to c peptide ratio and prolonged hyperglycemic time in type 2 diabetes |
| topic | proinsulin type 2 diabetes continuous glucose monitoring β-cell dysfunction |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/4/71_EJ23-0525/_html/-char/en |
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