Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes?
Objective:. Our aim was to assess whether complications after pancreatoduodenectomy (PD) impact long-term quality of life (QoL) and functional outcomes. Background:. There is an increasing number of long-term post-PD survivors, but few studies have evaluated long-term QoL outcomes. Methods:. The EOR...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2024-06-01
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| Series: | Annals of Surgery Open |
| Online Access: | http://journals.lww.com/10.1097/AS9.0000000000000400 |
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| author | Ajami Gikandi, BA Zhi Ven Fong, MD, MPH, DrPH Motaz Qadan, MD, PhD Raja R. Narayan, MD, MPH Thinzar Lwin, MD, MS Carlos Fernández-del Castillo, MD Keith D. Lillemoe, MD Cristina R. Ferrone, MD |
| author_facet | Ajami Gikandi, BA Zhi Ven Fong, MD, MPH, DrPH Motaz Qadan, MD, PhD Raja R. Narayan, MD, MPH Thinzar Lwin, MD, MS Carlos Fernández-del Castillo, MD Keith D. Lillemoe, MD Cristina R. Ferrone, MD |
| author_sort | Ajami Gikandi, BA |
| collection | DOAJ |
| description | Objective:. Our aim was to assess whether complications after pancreatoduodenectomy (PD) impact long-term quality of life (QoL) and functional outcomes.
Background:. There is an increasing number of long-term post-PD survivors, but few studies have evaluated long-term QoL outcomes.
Methods:. The EORTC QLQ-C30 and QLQ-PAN26 questionnaires were administered to patients who survived >5 years post-PD. Clinical relevance (CR) was scored as small (5–10), moderate (10–20), or large (>20). Patients were stratified based on whether they experienced a complication during the index hospitalization.
Results:. Of 305 patients >5 years post-PD survivors, with valid contact information, 248 completed the questionnaires, and 231 had complication data available. Twenty-nine percent of patients experienced a complication, of which 17 (7.4%) were grade 1, 27 (11.7%) were grade 2, and 25 (10.8%) were grade 3. Global health status and functional domain scores were similar between both groups. Patients experiencing complications reported lower fatigue (21.4 vs 28.1, P < 0.05, CR small) and diarrhea (15.9 vs 23.1, P < 0.05, CR small) symptom scores when compared to patients without complications. Patients experiencing complications also reported lower pancreatic pain (38.2 vs 43.4, P < 0.05, CR small) and altered bowel habits (30.1 vs 40.7, P < 0.01, CR moderate) symptom scores. There was a lower prevalence of worrying (36.2% vs 60.5%, P < 0.05) and bloating (42.0% vs 56.2%, P < 0.05) among PD survivors with complications.
Conclusions:. Post-PD complication rates were not associated with long-term global QoL or functionality, and may be associated with less severe pancreas-specific symptoms. |
| format | Article |
| id | doaj-art-5fa45e3527004995beeb41903c465b90 |
| institution | Kabale University |
| issn | 2691-3593 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Annals of Surgery Open |
| spelling | doaj-art-5fa45e3527004995beeb41903c465b902025-01-24T09:18:39ZengWolters Kluwer HealthAnnals of Surgery Open2691-35932024-06-0152e40010.1097/AS9.0000000000000400202406000-00002Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes?Ajami Gikandi, BA0Zhi Ven Fong, MD, MPH, DrPH1Motaz Qadan, MD, PhD2Raja R. Narayan, MD, MPH3Thinzar Lwin, MD, MS4Carlos Fernández-del Castillo, MD5Keith D. Lillemoe, MD6Cristina R. Ferrone, MD7* From the Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA† Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA† Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA† Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA‡ Department of Surgery, City of Hope National Medical Center, Duarte, CA† Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA† Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA§ Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.Objective:. Our aim was to assess whether complications after pancreatoduodenectomy (PD) impact long-term quality of life (QoL) and functional outcomes. Background:. There is an increasing number of long-term post-PD survivors, but few studies have evaluated long-term QoL outcomes. Methods:. The EORTC QLQ-C30 and QLQ-PAN26 questionnaires were administered to patients who survived >5 years post-PD. Clinical relevance (CR) was scored as small (5–10), moderate (10–20), or large (>20). Patients were stratified based on whether they experienced a complication during the index hospitalization. Results:. Of 305 patients >5 years post-PD survivors, with valid contact information, 248 completed the questionnaires, and 231 had complication data available. Twenty-nine percent of patients experienced a complication, of which 17 (7.4%) were grade 1, 27 (11.7%) were grade 2, and 25 (10.8%) were grade 3. Global health status and functional domain scores were similar between both groups. Patients experiencing complications reported lower fatigue (21.4 vs 28.1, P < 0.05, CR small) and diarrhea (15.9 vs 23.1, P < 0.05, CR small) symptom scores when compared to patients without complications. Patients experiencing complications also reported lower pancreatic pain (38.2 vs 43.4, P < 0.05, CR small) and altered bowel habits (30.1 vs 40.7, P < 0.01, CR moderate) symptom scores. There was a lower prevalence of worrying (36.2% vs 60.5%, P < 0.05) and bloating (42.0% vs 56.2%, P < 0.05) among PD survivors with complications. Conclusions:. Post-PD complication rates were not associated with long-term global QoL or functionality, and may be associated with less severe pancreas-specific symptoms.http://journals.lww.com/10.1097/AS9.0000000000000400 |
| spellingShingle | Ajami Gikandi, BA Zhi Ven Fong, MD, MPH, DrPH Motaz Qadan, MD, PhD Raja R. Narayan, MD, MPH Thinzar Lwin, MD, MS Carlos Fernández-del Castillo, MD Keith D. Lillemoe, MD Cristina R. Ferrone, MD Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? Annals of Surgery Open |
| title | Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? |
| title_full | Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? |
| title_fullStr | Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? |
| title_full_unstemmed | Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? |
| title_short | Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? |
| title_sort | do complications after pancreatoduodenectomy have an impact on long term quality of life and functional outcomes |
| url | http://journals.lww.com/10.1097/AS9.0000000000000400 |
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