mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae

mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae

ABSTRACT Klebsiella pneumoniae is a prominent Gram-negative and encapsulated opportunistic pathogen that causes a multitude of infections such as severe respiratory and healthcare-associated infections. Despite the widespread anti-microbial resistance and the high mortality rate, currently, no clini...

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Bibliographic Details
Main Authors: Ting Huang, Siyou Che, Zheng Lv, Danrui Hao, Runyu Wang, Qinxuan Yi, Ling Mei, Yang Yuan, Hang Zou, Yidong Guo, Xinrong Wang, Yiwen Chu, Kelei Zhao
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSphere
Subjects:
Klebsiella pneumoniae
mRNA vaccine
antibacterial immunity
virulence
Online Access:https://journals.asm.org/doi/10.1128/msphere.00775-24
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