The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia
Background/Aim. Immune system disorder, including inflammation, takes a significant place when considering still unclear etiology of schizophrenia. The aim of this study was to determine the blood levels of nonspecific inflammation markers in the first episode of schizophrenia and their rel...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500016S.pdf |
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| author | Stefanović Vesna Mihajlović Goran Nenadović Milutin Đukić-Dejanović Slavica Borovčanin Milica Trajković Goran |
| author_facet | Stefanović Vesna Mihajlović Goran Nenadović Milutin Đukić-Dejanović Slavica Borovčanin Milica Trajković Goran |
| author_sort | Stefanović Vesna |
| collection | DOAJ |
| description | Background/Aim. Immune system disorder, including inflammation, takes a
significant place when considering still unclear etiology of schizophrenia.
The aim of this study was to determine the blood levels of nonspecific
inflammation markers in the first episode of schizophrenia and their relation
to the therapy response. Methods. In this study we determined the blood
levels of nonspecific inflammation markers: white blood cells count (WBC),
C-reactive protein (CRP), erythrocytes sedimentation rate (ESR) and the
elements of differential white blood cell counts (or the leukocyte formula):
granulocytes (Gra), lymphocytes (Lym) and monocytes (Mon), in the first
episode of schizofrenia, in 78 patients hospitalized at the Clinic for
Psychiatric Disorders “Dr Laza Lazarević” in Belgrade. The levels were
measured at admission to the clinic, as well as after 4 weeks of
antipsychotic treatment. The Positive and negative syndrome scale for
schizophrenia (PANSS) was applied to measure the severity of psychopathology
and response to the treatment. Results. During the first episode of
schizophrenia, before initiation of antipsychotic treatment, the frequency of
abnormal values was high (≥ 25% of the patients) for the following
non-specific inflammation markers: WBC, CRP, ESR and Gra, in the leukocyte
formula, but dropped after 4 weeks of antipsychotic treatment at the level of
high statistical significance for WBC and Gra (p < 0.001). The ESR remained
unchanged in as many as 50% of the patients even after 4-week antipsychotic
treatment, at the level of statistical significance in the non-responders
compared to the responders (p = 0.045). Conclusion. The obtained results
indicate that in the first episode of schizophrenia the blood levels of
non-specific inflammation markers (WBS, CRP, ESR and Gra from the leukocyte
formula) were high in the subpopulation of patients with the tendency towards
normalization of inflammation parameters after a 4-week antipsychotic
treatment. |
| format | Article |
| id | doaj-art-5f9d4c4afd9e4a6faa2eae69b2bebb0d |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-5f9d4c4afd9e4a6faa2eae69b2bebb0d2025-08-20T02:23:39ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202015-01-0172121085109210.2298/VSP140526016S0042-84501500016SThe effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophreniaStefanović Vesna0Mihajlović Goran1Nenadović Milutin2Đukić-Dejanović Slavica3Borovčanin Milica4Trajković Goran5Clinic for Psychiatric Disorders „Dr Laza Lazarević“, BelgradeFaculty of Medical Sciences, KragujevacClinic for Psychiatric Disorders „Dr Laza Lazarević“, BelgradeClinic for Psychiatric Disorders „Dr Laza Lazarević“, Belgrade + Faculty of Medical Sciences, KragujevacFaculty of Medical Sciences, KragujevacFaculty of Medicine, Institute of Medical Statistics and Informatics, BelgradeBackground/Aim. Immune system disorder, including inflammation, takes a significant place when considering still unclear etiology of schizophrenia. The aim of this study was to determine the blood levels of nonspecific inflammation markers in the first episode of schizophrenia and their relation to the therapy response. Methods. In this study we determined the blood levels of nonspecific inflammation markers: white blood cells count (WBC), C-reactive protein (CRP), erythrocytes sedimentation rate (ESR) and the elements of differential white blood cell counts (or the leukocyte formula): granulocytes (Gra), lymphocytes (Lym) and monocytes (Mon), in the first episode of schizofrenia, in 78 patients hospitalized at the Clinic for Psychiatric Disorders “Dr Laza Lazarević” in Belgrade. The levels were measured at admission to the clinic, as well as after 4 weeks of antipsychotic treatment. The Positive and negative syndrome scale for schizophrenia (PANSS) was applied to measure the severity of psychopathology and response to the treatment. Results. During the first episode of schizophrenia, before initiation of antipsychotic treatment, the frequency of abnormal values was high (≥ 25% of the patients) for the following non-specific inflammation markers: WBC, CRP, ESR and Gra, in the leukocyte formula, but dropped after 4 weeks of antipsychotic treatment at the level of high statistical significance for WBC and Gra (p < 0.001). The ESR remained unchanged in as many as 50% of the patients even after 4-week antipsychotic treatment, at the level of statistical significance in the non-responders compared to the responders (p = 0.045). Conclusion. The obtained results indicate that in the first episode of schizophrenia the blood levels of non-specific inflammation markers (WBS, CRP, ESR and Gra from the leukocyte formula) were high in the subpopulation of patients with the tendency towards normalization of inflammation parameters after a 4-week antipsychotic treatment.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500016S.pdfschizophreniaantipsychotic agentsinflammation mediatorssensitivity and specificitypredictive value of tests |
| spellingShingle | Stefanović Vesna Mihajlović Goran Nenadović Milutin Đukić-Dejanović Slavica Borovčanin Milica Trajković Goran The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia Vojnosanitetski Pregled schizophrenia antipsychotic agents inflammation mediators sensitivity and specificity predictive value of tests |
| title | The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia |
| title_full | The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia |
| title_fullStr | The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia |
| title_full_unstemmed | The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia |
| title_short | The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia |
| title_sort | effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia |
| topic | schizophrenia antipsychotic agents inflammation mediators sensitivity and specificity predictive value of tests |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500016S.pdf |
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