Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia
Introduction: The pathogenesis of renal disease in obesity and metabolic syndrome (MS) is mostly unknown. This is in part because of the limited information about renal morphological changes in these conditions. We evaluated renal histology in subjects with MS and those without MS, who are participa...
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Elsevier
2024-05-01
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| Series: | Kidney International Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024924014931 |
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| author | Rosa Rodríguez-Rodríguez Mads Hornum Ana Elena Rodríguez Rodríguez Sebastjan Bevc Francesco Trevisani Gema Fernández Radovan Hojs Beatriz Fernández-Fernández Clara María Cases Corona Josep María Cruzado María Quero Maruja Navarro Díaz Arianna Bettiga Francisco Moreso Clara García Carro Khaled Khazim Fedaa Ghanem Meritxell Ibernón Ivo Laranjinhia Luís Mendonça Miguel Bigotte Vieira Bo Feldt-Rasmussen Alberto Ortiz Per Bagi Cristian Acosta Sorensen Enrique Morales Esteban Porrini Radovan Hojs Sebastjan Bevc Gema Fernández Clara María Cases Corona María Quero Laia Pujol Sergi Beato Montserrat Gomà Josep Cruzado Meritxell Ibernon Francisco Moreso Marina López-Martínez; Mads Hornum Bo Feldt-Rasmussen; Alberto Ortíz Beatriz Fernández-Fernandez Elena Gomá-Garces Teresa Stock da Cunha Ana B. Sanz María Garranzo Carmen Gonzalez-Enguita Ana María Autrán-Gómez; Pablo Cannata Khalid Khazim Fedaa Ghanem Esteban Porrini Rosa Rodríguez-Rodríguez Natalia Negrín Mena Tomás Concepción; Ivo Laranjinhia Luís Mendonça; Miguel Bigotte Vieira Trevisani Francesco Arianna Bettiga Federico Di Marco Andrea Salonia Francesco Montorsi Dell'Antonia Giacomo Enrique Morales Manuel Praga |
| author_facet | Rosa Rodríguez-Rodríguez Mads Hornum Ana Elena Rodríguez Rodríguez Sebastjan Bevc Francesco Trevisani Gema Fernández Radovan Hojs Beatriz Fernández-Fernández Clara María Cases Corona Josep María Cruzado María Quero Maruja Navarro Díaz Arianna Bettiga Francisco Moreso Clara García Carro Khaled Khazim Fedaa Ghanem Meritxell Ibernón Ivo Laranjinhia Luís Mendonça Miguel Bigotte Vieira Bo Feldt-Rasmussen Alberto Ortiz Per Bagi Cristian Acosta Sorensen Enrique Morales Esteban Porrini Radovan Hojs Sebastjan Bevc Gema Fernández Clara María Cases Corona María Quero Laia Pujol Sergi Beato Montserrat Gomà Josep Cruzado Meritxell Ibernon Francisco Moreso Marina López-Martínez; Mads Hornum Bo Feldt-Rasmussen; Alberto Ortíz Beatriz Fernández-Fernandez Elena Gomá-Garces Teresa Stock da Cunha Ana B. Sanz María Garranzo Carmen Gonzalez-Enguita Ana María Autrán-Gómez; Pablo Cannata Khalid Khazim Fedaa Ghanem Esteban Porrini Rosa Rodríguez-Rodríguez Natalia Negrín Mena Tomás Concepción; Ivo Laranjinhia Luís Mendonça; Miguel Bigotte Vieira Trevisani Francesco Arianna Bettiga Federico Di Marco Andrea Salonia Francesco Montorsi Dell'Antonia Giacomo Enrique Morales Manuel Praga |
| author_sort | Rosa Rodríguez-Rodríguez |
| collection | DOAJ |
| description | Introduction: The pathogenesis of renal disease in obesity and metabolic syndrome (MS) is mostly unknown. This is in part because of the limited information about renal morphological changes in these conditions. We evaluated renal histology in subjects with MS and those without MS, who are participants in the European Nephrectomy Biobank (ENBiBA) project. Methods: MS was defined with at least 3 of the following criteria: (i) body mass index (BMI) ≥27 kg/m2; (ii) prediabetes: fasting glucose of 100–125 mg/dl or HbA1c >5.7%; (iii) systolic or diastolic blood pressure >140/90 mm Hg or the use of medications; and (iv) triglycerides >150 mg/dl or high-density lipoprotein cholesterol <40 (in men) or 50 mg/dl (in women). The absence of these criteria defined patients without MS. Exclusion criteria were diabetes or known causes of renal disease. Results: A total of 157 cases were evaluated: 49 without and 108 with MS. Those with MS were older (54 ± 16 vs. 66 ± 11, P < 0.0001), had more prevalent chronic kidney disease (CKD, estimated glomerular filtration rate [eGFR] <60 ml/min): 24% (23%) versus 4% (8%) (P = 0.02), and had higher albumin-to-creatinine ratio (10 [4–68] vs. 4.45 [0–27], P = 0.05) than those without MS. Global sclerosis (3% [1–7] vs. 7% [3–13], P < 0.0001), nodular sclerosis, mesangial expansion, glomerulomegaly; moderate + severe hyalinosis, and arteriosclerosis were more frequent in those with MS than in those without (88 [82] vs. 29 [59]; 83 [77] vs. 30 [61]; P < 0.05). These vascular changes were independent of differences in age. Conclusion: In MS, ischemic renal disease may play a role in renal disease. In addition, some patients may develop lesions compatible with diabetic nephropathy such as increased mesangial expansion and nodular sclerosis. Further analyses are needed to study the consequences of the pandemic of obesity on renal health. |
| format | Article |
| id | doaj-art-5f9c80bf69c540318c07bb8f1fa4c6e8 |
| institution | DOAJ |
| issn | 2468-0249 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj-art-5f9c80bf69c540318c07bb8f1fa4c6e82025-08-20T03:21:14ZengElsevierKidney International Reports2468-02492024-05-01951419142810.1016/j.ekir.2024.02.1403Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal IschemiaRosa Rodríguez-Rodríguez0Mads Hornum1Ana Elena Rodríguez Rodríguez2Sebastjan Bevc3Francesco Trevisani4Gema Fernández5Radovan Hojs6Beatriz Fernández-Fernández7Clara María Cases Corona8Josep María Cruzado9María Quero10Maruja Navarro Díaz11Arianna Bettiga12Francisco Moreso13Clara García Carro14Khaled Khazim15Fedaa Ghanem16Meritxell Ibernón17Ivo Laranjinhia18Luís Mendonça19Miguel Bigotte Vieira20Bo Feldt-Rasmussen21Alberto Ortiz22Per Bagi23Cristian Acosta Sorensen24Enrique Morales25Esteban Porrini26Radovan HojsSebastjan BevcGema FernándezClara María Cases CoronaMaría QueroLaia PujolSergi Beato Montserrat GomàJosep CruzadoMeritxell IbernonFrancisco MoresoMarina López-Martínez; Mads HornumBo Feldt-Rasmussen; Alberto OrtízBeatriz Fernández-FernandezElena Gomá-GarcesTeresa Stock da CunhaAna B. SanzMaría GarranzoCarmen Gonzalez-EnguitaAna María Autrán-Gómez; Pablo CannataKhalid KhazimFedaa GhanemEsteban PorriniRosa Rodríguez-RodríguezNatalia Negrín MenaTomás Concepción; Ivo LaranjinhiaLuís Mendonça; Miguel Bigotte VieiraTrevisani FrancescoArianna BettigaFederico Di MarcoAndrea SaloniaFrancesco MontorsiDell'Antonia GiacomoEnrique MoralesManuel PragaHospital Universitario de Canarias, Pathology Department. Tenerife, Spain; Faculty of Medicine, University of La Laguna, Tenerife, SpainRigshospitalet, Copenhagen, DenmarkResearch Unit, Hospital Universitario de Canarias, Tenerife, SpainDepartment of Nephrology, Clinic for Internal Medicine, University Clinical Centre Maribor and Faculty of Medicine, University of Maribor, SloveniaIRCCS Ospedale San Raffaele, URI-Urological Research Institute, Milano, ItalyHospital La Paz, Nephrology Department. Madrid, SpainDepartment of Nephrology, Clinic for Internal Medicine, University Clinical Centre Maribor and Faculty of Medicine, University of Maribor, SloveniaIIS-Fundación Jiménez Díaz-UAM, Madrid, Spain; REDINREN ISCIII, Madrid, SpainHospital Universitario Fundación Alcorcón, Madrid, SpainNephrology Department. Hospital Universitario de Bellvitge. Biomedical Research Institute (IDIBELL). Departamento de Ciencias Clínicas, Facultad de Medicina, Universidad de Barcelona. Hospitalet de Llobregat, SpainNephrology Department. Hospital Universitario de Bellvitge. Biomedical Research Institute (IDIBELL). Departamento de Ciencias Clínicas, Facultad de Medicina, Universidad de Barcelona. Hospitalet de Llobregat, SpainHospital Moisés Broggi, Nephrology Department. Barcelona, SpainIRCCS Ospedale San Raffaele, URI-Urological Research Institute, Milano, ItalyHospital Universitario Vall d'Hebron, Barcelona, SpainHospital Universitario Clínico San Carlos, Nephrology Department, Madrid, SpainGalilee Medical Center, Nahariya, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, IsraelGalilee Medical Center, Nahariya, Azrieli Faculty of Medicine, Bar-Ilan University, Safed, IsraelHospital Moisés Broggi, Nephrology Department. Barcelona, SpainHospital de Santa Cruz Lisboa, Lisboa, PortugalCentro Hospitalar Lisboa Norte, Lisboa, PortugalCentro Hospitalar São João, Porto, PortugalRigshospitalet, Copenhagen, DenmarkIIS-Fundación Jiménez Díaz-UAM, Madrid, Spain; REDINREN ISCIII, Madrid, SpainDepartment of Urology, Faculty of Health and Medical Sciences, University of Copenhagen, Rigshospitalet, DenmarkResearch Unit, Hospital Universitario de Canarias, Tenerife, SpainHospital 12 de Octubre, Madrid, SpainFaculty of Medicine, University of La Laguna, Tenerife, Spain; Research Unit, Hospital Universitario de Canarias, Tenerife, Spain; ITB: Instituto de Tecnología Biomédicas, University of La Laguna, Tenerife, Spain; Correspondence: Esteban Porrini, Hospital Universitario de Canarias, Ofra S/N 38320 La Laguna, Tenerife,Spain.Introduction: The pathogenesis of renal disease in obesity and metabolic syndrome (MS) is mostly unknown. This is in part because of the limited information about renal morphological changes in these conditions. We evaluated renal histology in subjects with MS and those without MS, who are participants in the European Nephrectomy Biobank (ENBiBA) project. Methods: MS was defined with at least 3 of the following criteria: (i) body mass index (BMI) ≥27 kg/m2; (ii) prediabetes: fasting glucose of 100–125 mg/dl or HbA1c >5.7%; (iii) systolic or diastolic blood pressure >140/90 mm Hg or the use of medications; and (iv) triglycerides >150 mg/dl or high-density lipoprotein cholesterol <40 (in men) or 50 mg/dl (in women). The absence of these criteria defined patients without MS. Exclusion criteria were diabetes or known causes of renal disease. Results: A total of 157 cases were evaluated: 49 without and 108 with MS. Those with MS were older (54 ± 16 vs. 66 ± 11, P < 0.0001), had more prevalent chronic kidney disease (CKD, estimated glomerular filtration rate [eGFR] <60 ml/min): 24% (23%) versus 4% (8%) (P = 0.02), and had higher albumin-to-creatinine ratio (10 [4–68] vs. 4.45 [0–27], P = 0.05) than those without MS. Global sclerosis (3% [1–7] vs. 7% [3–13], P < 0.0001), nodular sclerosis, mesangial expansion, glomerulomegaly; moderate + severe hyalinosis, and arteriosclerosis were more frequent in those with MS than in those without (88 [82] vs. 29 [59]; 83 [77] vs. 30 [61]; P < 0.05). These vascular changes were independent of differences in age. Conclusion: In MS, ischemic renal disease may play a role in renal disease. In addition, some patients may develop lesions compatible with diabetic nephropathy such as increased mesangial expansion and nodular sclerosis. Further analyses are needed to study the consequences of the pandemic of obesity on renal health.http://www.sciencedirect.com/science/article/pii/S2468024924014931diabetic nephropathymetabolic syndromevascular disease |
| spellingShingle | Rosa Rodríguez-Rodríguez Mads Hornum Ana Elena Rodríguez Rodríguez Sebastjan Bevc Francesco Trevisani Gema Fernández Radovan Hojs Beatriz Fernández-Fernández Clara María Cases Corona Josep María Cruzado María Quero Maruja Navarro Díaz Arianna Bettiga Francisco Moreso Clara García Carro Khaled Khazim Fedaa Ghanem Meritxell Ibernón Ivo Laranjinhia Luís Mendonça Miguel Bigotte Vieira Bo Feldt-Rasmussen Alberto Ortiz Per Bagi Cristian Acosta Sorensen Enrique Morales Esteban Porrini Radovan Hojs Sebastjan Bevc Gema Fernández Clara María Cases Corona María Quero Laia Pujol Sergi Beato Montserrat Gomà Josep Cruzado Meritxell Ibernon Francisco Moreso Marina López-Martínez; Mads Hornum Bo Feldt-Rasmussen; Alberto Ortíz Beatriz Fernández-Fernandez Elena Gomá-Garces Teresa Stock da Cunha Ana B. Sanz María Garranzo Carmen Gonzalez-Enguita Ana María Autrán-Gómez; Pablo Cannata Khalid Khazim Fedaa Ghanem Esteban Porrini Rosa Rodríguez-Rodríguez Natalia Negrín Mena Tomás Concepción; Ivo Laranjinhia Luís Mendonça; Miguel Bigotte Vieira Trevisani Francesco Arianna Bettiga Federico Di Marco Andrea Salonia Francesco Montorsi Dell'Antonia Giacomo Enrique Morales Manuel Praga Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia Kidney International Reports diabetic nephropathy metabolic syndrome vascular disease |
| title | Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia |
| title_full | Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia |
| title_fullStr | Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia |
| title_full_unstemmed | Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia |
| title_short | Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia |
| title_sort | renal disease in metabolic syndrome the hidden role of intrarenal ischemia |
| topic | diabetic nephropathy metabolic syndrome vascular disease |
| url | http://www.sciencedirect.com/science/article/pii/S2468024924014931 |
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