Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)
Mannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no c...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/469128 |
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| author | J.-Gonzalo Ocejo-Vinyals Lucía Lavín-Alconero Pablo Sánchez-Velasco M.-Ángeles Guerrero-Alonso Fernando Ausín M.-Carmen Fariñas Francisco Leyva-Cobián |
| author_facet | J.-Gonzalo Ocejo-Vinyals Lucía Lavín-Alconero Pablo Sánchez-Velasco M.-Ángeles Guerrero-Alonso Fernando Ausín M.-Carmen Fariñas Francisco Leyva-Cobián |
| author_sort | J.-Gonzalo Ocejo-Vinyals |
| collection | DOAJ |
| description | Mannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no convincing evidence of association between mannose-binding lectin 2 and susceptibility to tuberculosis. For this reason, we conducted a study in a well genetically conserved Spanish population in order to shed light on this controversial association. We analysed the six promoter and structural mannose-binding lectin 2 gene variants in 107 patients with pulmonary tuberculosis and 441 healthy controls. Only D variant and HYPD haplotype were significantly more frequents in controls which would indicate that this allele could confer protection against pulmonary tuberculosis, but this difference disappeared after statistical correction. Neither the rest of alleles nor the haplotypes were significantly associated with the disease. These results would indicate that mannose-binding lectin promoter polymorphisms and gene variants would not be associated with an increased risk to pulmonary tuberculosis. Despite the slight trend of the D allele and HYPD haplotype in conferring protection against pulmonary tuberculosis, susceptibility to this disease would probably be due to other genetic factors, at least in our population. |
| format | Article |
| id | doaj-art-5f9ba4883e0c44e98c99a87c5e8949a0 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-5f9ba4883e0c44e98c99a87c5e8949a02025-02-03T01:32:41ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/469128469128Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)J.-Gonzalo Ocejo-Vinyals0Lucía Lavín-Alconero1Pablo Sánchez-Velasco2M.-Ángeles Guerrero-Alonso3Fernando Ausín4M.-Carmen Fariñas5Francisco Leyva-Cobián6Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Avenida de Valdecilla s/n, 39008 Santander, SpainServicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Avenida de Valdecilla s/n, 39008 Santander, SpainServicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Avenida de Valdecilla s/n, 39008 Santander, SpainServicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Avenida de Valdecilla s/n, 39008 Santander, SpainServicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Avenida de Valdecilla s/n, 39008 Santander, SpainUnidad de Enfermedades Infecciosas, Departamento de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, 39011 Santander, SpainServicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Avenida de Valdecilla s/n, 39008 Santander, SpainMannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no convincing evidence of association between mannose-binding lectin 2 and susceptibility to tuberculosis. For this reason, we conducted a study in a well genetically conserved Spanish population in order to shed light on this controversial association. We analysed the six promoter and structural mannose-binding lectin 2 gene variants in 107 patients with pulmonary tuberculosis and 441 healthy controls. Only D variant and HYPD haplotype were significantly more frequents in controls which would indicate that this allele could confer protection against pulmonary tuberculosis, but this difference disappeared after statistical correction. Neither the rest of alleles nor the haplotypes were significantly associated with the disease. These results would indicate that mannose-binding lectin promoter polymorphisms and gene variants would not be associated with an increased risk to pulmonary tuberculosis. Despite the slight trend of the D allele and HYPD haplotype in conferring protection against pulmonary tuberculosis, susceptibility to this disease would probably be due to other genetic factors, at least in our population.http://dx.doi.org/10.1155/2012/469128 |
| spellingShingle | J.-Gonzalo Ocejo-Vinyals Lucía Lavín-Alconero Pablo Sánchez-Velasco M.-Ángeles Guerrero-Alonso Fernando Ausín M.-Carmen Fariñas Francisco Leyva-Cobián Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) Pulmonary Medicine |
| title | Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) |
| title_full | Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) |
| title_fullStr | Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) |
| title_full_unstemmed | Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) |
| title_short | Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain) |
| title_sort | mannose binding lectin promoter polymorphisms and gene variants in pulmonary tuberculosis patients from cantabria northern spain |
| url | http://dx.doi.org/10.1155/2012/469128 |
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