Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports
Abstract Background Effects of subthalamic nucleus deep brain stimulation (STN-DBS) on neuropsychiatric symptoms of Parkinson’s disease (PD) remain debated. Sensor technology might help to objectively assess behavioural changes after STN-DBS. Case presentation 5 PD patients were assessed 1 before an...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04030-w |
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| author | Lena C. Bruhin Michael Single Aileen C. Naef Katrin Petermann Mario Sousa Matilde Castelli Ines Debove Marie E. Maradan-Gachet Andreia D. Magalhães Andreas A. Diamantaras M. Lenard Lachenmayer Gerd Tinkhauser Julia Waskönig Christopher M. el Achkar Alia Lemkaddem Mathieu Lemay Paul Krack Tobias Nef Deborah Amstutz |
| author_facet | Lena C. Bruhin Michael Single Aileen C. Naef Katrin Petermann Mario Sousa Matilde Castelli Ines Debove Marie E. Maradan-Gachet Andreia D. Magalhães Andreas A. Diamantaras M. Lenard Lachenmayer Gerd Tinkhauser Julia Waskönig Christopher M. el Achkar Alia Lemkaddem Mathieu Lemay Paul Krack Tobias Nef Deborah Amstutz |
| author_sort | Lena C. Bruhin |
| collection | DOAJ |
| description | Abstract Background Effects of subthalamic nucleus deep brain stimulation (STN-DBS) on neuropsychiatric symptoms of Parkinson’s disease (PD) remain debated. Sensor technology might help to objectively assess behavioural changes after STN-DBS. Case presentation 5 PD patients were assessed 1 before and 5 months after STN-DBS with the Movement Disorders Society Unified Parkinson’s Disease Rating Scale part III in the medication ON (plus postoperatively stimulation ON) condition, the Montreal Cognitive Assessment, the Questionnaire for Impulsive-Compulsive Behaviors in Parkinson’s Disease Rating Scale present version, the Hospital Anxiety and Depression Scale and the Starkstein Apathy Scale. Steps taken per hour, nighttime spent in bed and time spent outside were monitored with a smartwatch and ambient sensors placed in patient homes for an average of 20 days pre- and postoperatively. Postoperative improvement in ICDs and concomitant anxious-depressive symptoms was observed in 3 patients and was accompanied by a decrease in steps taken per hour, as well as an increase in nighttime spent in bed. In the two patients without baseline ICDs, mild anxiety and apathy improved postoperatively, and no new neuropsychiatric symptoms occurred. Steps taken per hour did not decrease in these cases and nighttime spent in bed improved in one of the patients, but decreased in the other, who had experienced pain during OFF-phases at night before STN-DBS. Conclusion Changes in neuropsychiatric symptoms are associated with distinct activity patterns after STN-DBS, and wearable and ambient sensors may aid to capture those gradual shifts in behavior. |
| format | Article |
| id | doaj-art-5f9418a04c664517baafc5f9bbf0adf0 |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-5f9418a04c664517baafc5f9bbf0adf02025-01-19T12:28:04ZengBMCBMC Neurology1471-23772025-01-012511710.1186/s12883-025-04030-wChanges in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reportsLena C. Bruhin0Michael Single1Aileen C. Naef2Katrin Petermann3Mario Sousa4Matilde Castelli5Ines Debove6Marie E. Maradan-Gachet7Andreia D. Magalhães8Andreas A. Diamantaras9M. Lenard Lachenmayer10Gerd Tinkhauser11Julia Waskönig12Christopher M. el Achkar13Alia Lemkaddem14Mathieu Lemay15Paul Krack16Tobias Nef17Deborah Amstutz18ARTORG Center for Biomedical Engineering Research, University of BernARTORG Center for Biomedical Engineering Research, University of BernARTORG Center for Biomedical Engineering Research, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernARTORG Center for Biomedical Engineering Research, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernCentre Suisse d’Electronique et de MicrotechniqueCentre Suisse d’Electronique et de MicrotechniqueCentre Suisse d’Electronique et de MicrotechniqueDepartment of Neurology, University Hospital Bern, Inselspital, University of BernARTORG Center for Biomedical Engineering Research, University of BernDepartment of Neurology, University Hospital Bern, Inselspital, University of BernAbstract Background Effects of subthalamic nucleus deep brain stimulation (STN-DBS) on neuropsychiatric symptoms of Parkinson’s disease (PD) remain debated. Sensor technology might help to objectively assess behavioural changes after STN-DBS. Case presentation 5 PD patients were assessed 1 before and 5 months after STN-DBS with the Movement Disorders Society Unified Parkinson’s Disease Rating Scale part III in the medication ON (plus postoperatively stimulation ON) condition, the Montreal Cognitive Assessment, the Questionnaire for Impulsive-Compulsive Behaviors in Parkinson’s Disease Rating Scale present version, the Hospital Anxiety and Depression Scale and the Starkstein Apathy Scale. Steps taken per hour, nighttime spent in bed and time spent outside were monitored with a smartwatch and ambient sensors placed in patient homes for an average of 20 days pre- and postoperatively. Postoperative improvement in ICDs and concomitant anxious-depressive symptoms was observed in 3 patients and was accompanied by a decrease in steps taken per hour, as well as an increase in nighttime spent in bed. In the two patients without baseline ICDs, mild anxiety and apathy improved postoperatively, and no new neuropsychiatric symptoms occurred. Steps taken per hour did not decrease in these cases and nighttime spent in bed improved in one of the patients, but decreased in the other, who had experienced pain during OFF-phases at night before STN-DBS. Conclusion Changes in neuropsychiatric symptoms are associated with distinct activity patterns after STN-DBS, and wearable and ambient sensors may aid to capture those gradual shifts in behavior.https://doi.org/10.1186/s12883-025-04030-wParkinson’s diseaseDeep brain stimulationNeuropsychiatric symptomsSensor technologyObjective assessment |
| spellingShingle | Lena C. Bruhin Michael Single Aileen C. Naef Katrin Petermann Mario Sousa Matilde Castelli Ines Debove Marie E. Maradan-Gachet Andreia D. Magalhães Andreas A. Diamantaras M. Lenard Lachenmayer Gerd Tinkhauser Julia Waskönig Christopher M. el Achkar Alia Lemkaddem Mathieu Lemay Paul Krack Tobias Nef Deborah Amstutz Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports BMC Neurology Parkinson’s disease Deep brain stimulation Neuropsychiatric symptoms Sensor technology Objective assessment |
| title | Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports |
| title_full | Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports |
| title_fullStr | Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports |
| title_full_unstemmed | Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports |
| title_short | Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports |
| title_sort | changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for parkinson s disease 5 case reports |
| topic | Parkinson’s disease Deep brain stimulation Neuropsychiatric symptoms Sensor technology Objective assessment |
| url | https://doi.org/10.1186/s12883-025-04030-w |
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